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TranscriptomicsSystemic lupus erythematosus
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-46923 | biostudies-arrayexpress
TranscriptomicsTranscriptional Profiling is Superior to Procalcitonin to Discriminate Bacterial vs. Viral Lower Respiratory Tract Infections in Hospitalized Adults
Background: Distinguishing between bacterial and viral lower respiratory tract infections (LRTI) in hospitalized patients remains challenging. Transcriptional profiling is a promising tool for improving diagnosis in LRTI. Methods: We performed whole blood transcriptional analysis in a cohort of ...
ORGANISM(S): Homo sapiens 
2015-09-14 | E-GEOD-60244 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human stemic juvenile idiopathic arthritis, , systemic lupus erythematosus,, type I diabetes, metastatic melanoma, acute infections, or liver-transplant recipients undergoing immunosuppressive therapy (n = 37)
The analysis of patient blood transcriptional profiles offers a means to investigate the immunological mechanisms relevant to human diseases on a genome-wide scale. In addition, such studies provide a basis for the discovery of clinically relevant biomarker signatures. We designed a strategy for mic...
ORGANISM(S): Homo sapiens 
2008-10-04 | E-GEOD-11907 | biostudies-arrayexpress
TranscriptomicsTranscripts induced by exposure to SLE serum in healthy blood monocytes
Monocytes from 3 healthy donors were cultured for 6 hours in the presence of 20% serum from three newly diagnosed, untreated SLE patients. Microarray analysis was then performed upon normalizing the gene expression levels of samples incubated with SLE sera to those incubated with autologous serum. M...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-46920 | biostudies-arrayexpress
TranscriptomicsDefining RNA Transcriptional Biosignatures to Distinguish Febrile Infants 60 Days of Age and Younger with Bacterial vs Non-Bacterial Infections
The use of microbiological cultures for diagnosing bacterial infections in young febrile infants have substantial limitations, including false positive and false negative cultures, and non-ideal turn-around times. Analysis of host genomic expression patterns (“RNA biosignatures”) in response to ...
ORGANISM(S): Homo sapiens 
2016-07-27 | E-GEOD-64456 | biostudies-arrayexpress
TranscriptomicsGenomic Fingerprints of DC Subsets in the Human Vaginal Mucosa, Skin, and Blood
Dendritic cells (DC) localize throughout the body, where they sense and capture invading pathogens to induce protective immune responses. Hence, harnessing the biology of tissue-resident DC is crucial for the rational design of vaccines against pathogens. Herein, we characterized the transcriptomes ...
ORGANISM(S): Homo sapiens 
2014-12-17 | E-GEOD-54480 | biostudies-arrayexpress
TranscriptomicsTranscripts differentially expressed in healthy blood mDCs compared to healthy monocytes
To directly compare the SLE monocyte transcriptional program with that of blood mDC precursors, we purified lineage HLA-DRhighCD11chigh mDCs and CD14+ monocytes from the blood of five healthy donors. Their gene expression profiles were then compared to those of blood SLE monocytes. An unsupervised c...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-46913 | biostudies-arrayexpress
TranscriptomicsDifferentially expressed transcripts in SLE blood monocytes according to their capacity to induce mixed lymphocytic reaction
We screened SLE monocytes from 19 SLE patients and selected 4 that induced CD4+ T cell proliferation in vitro and 4 that did not. CFSE labeled CD4-T cells (105) were incubated with SLE monocytes (2 x 104). Cells were harvested at 6 hours for RNA extraction. We screened SLE monocytes from 19 SLE pati...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-46917 | biostudies-arrayexpress
TranscriptomicsSLE serum induced transcripts regulated by IFNa2b
To explore the full extent of IFN-regulated transcriptional changes, we exposed monocytes from two healthy donors to recombinant type I IFN (IFN-M-NM-12b) in vitro. RNA was extracted at 6 hrs and the expression data was normalized to that of monocytes cultured with medium. Blood monocytes isolated f...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-46921 | biostudies-arrayexpress
TranscriptomicsDifferentially expressed transcripts in SLE blood monocytes
To better characterize the molecules that could potentially confer antigen presenting capacity to SLE monocytes, we assessed their gene expression profile. Blood monocytes from five healthy controls and five pediatric SLE patients were isolated using CD14+ selection. Because drugs used to treat SLE ...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-46907 | biostudies-arrayexpress
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