Sort   by:  
 Page size 
TranscriptomicsIL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-12-12 | E-GEOD-75939 | biostudies-arrayexpress
TranscriptomicsIdentification of novel markers in rheumatoid arthritis through integrated analysis of DNA methylation and microRNA expression
Autoimmune rheumatic diseases are complex disorders, whose etiopathology is attributed to a crosstalk between genetic predisposition and environmental factors. Both variants of autoimmune susceptibility genes and environment are involved in the generation of aberrant epigenetic profiles in a cell-sp...
ORGANISM(S): Homo sapiens 
2013-05-07 | E-GEOD-46650 | biostudies-arrayexpress
TranscriptomicsIdentification of DNA methylation changes in monocytes to osteoclast differentiation
Conversion of monocytes to osteoclasts is a unique terminal differentiation process within the hematopoietic system involving differentiation and massive cell fusion. Here we focused on DNA methylation changes during osteoclastogenesis. Hypermethylation and hypomethylation changes took place in seve...
ORGANISM(S): Homo sapiens 
2013-08-30 | E-GEOD-46648 | biostudies-arrayexpress
UnknownSampling time-dependent artifacts in single-cell genomics studies.
Not available
S-EPMC7212672 | biostudies-literature
TranscriptomicsChanges in the Pattern of DNA Methylation Associate with Twin Discordance in SLE
This is the first high-throughput analysis of DNA methylation in autoimmune diseases. We have used a cohort of MZ twins discordant for three diseases whose clinical signs often overlap: systemic lupus erythematosus (SLE), rheumatoid arthritis and dermatomyositis. Only MZ twins discordant for SLE fea...
ORGANISM(S): Homo sapiens 
2009-11-16 | E-GEOD-19033 | biostudies-arrayexpress
TranscriptomicsComparison of the DNA methylation profiles of CD19+ B lymphocytes of a pair of monozygotic twins discordant for common variable immunodeficiency
The methylation profiles of bisulfite-modified DNA of CD19+ cells from MZ twins discordant for CVID were compared using the Infinium HumanMethylation450 BeadChips (Illumina, Inc., San Diego, CA,). This platform allows the interrogation of >485,000 methylation sites per sample at single-nucleotide re...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-63849 | biostudies-arrayexpress
TranscriptomicsComparison of the DNA methylation profiles of CD14+ monocytes from human peripheral blood with DCs and MACs obtained by exposure with GM-CSF/IL-4 and GM-CSF, respectively, and with mature DCs and MACs after LPS exposure
Comparison of the DNA methylation profiles of CD14+ monocytes from human peripheral blood with derived dendritic cells (DCs) and macrophages (MACs) obtained by exposure with GM-CSF/IL-4 and GM-CSF, respectively, and with mature DCs and MACs after lipopolysaccharide (LPS) exposure The methylation pro...
ORGANISM(S): Homo sapiens 
2015-12-11 | E-GEOD-71837 | biostudies-arrayexpress
TranscriptomicsMethylation data and effect of JAK3 inhibition on human MO-to-DC and MO-to-MAC differentiation
Comparison of the DNA methylation profiles of CD14+ monocytes from human peripheral blood with derived dendritic cells (DCs) and macrophages (MACs) obtained by exposure with GM-CSF/IL-4 and GM-CSF, respectively. Effects on the methylation profiles of DCs and MACs of JAK3 inhibitor PF-956980 The meth...
ORGANISM(S): Homo sapiens 
2015-12-12 | E-GEOD-75937 | biostudies-arrayexpress
TranscriptomicsUse of the B cell transcription program results in hypomethylation and overexpression of key genes in EBV-mediated conversion of resting to proliferative B cells
We investigated the effects of experimental EBV infection of B cells on DNA methylation profiles by using high-throughput analysis. Remarkably, we observed hypomethylation of around 250 genes, but no hypermethylation. Hypomethylation did not occur at repetitive sequences, consistent with the absence...
ORGANISM(S): Homo sapiens 
2012-12-20 | E-GEOD-41957 | biostudies-arrayexpress
ProteomicsM.musculus - B cell, iBAQ (Gomez-cabreroetal,scidata2019)
abundance based on iBAQ, Interaction consistency score: 10.0, Coverage: 8
ORGANISM(S): 10090 
2019-00-00 | 3223737855 | PAXDB
Sort   by:  
 Page size