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GenomicsA CpG mutational hotspot in a ONECUT (HNF6) binding site accounts for the prevalent variant of Hemophilia B Leyden
Hemophilia B, or the 'Royal Disease', arises from mutations in the Coagulation Factor IX (F9) gene. Mutations within the F9 promoter are associated with a remarkable form of the disease, termed Hemophilia B Leyden, in which symptoms ameliorate after puberty. Mutations at the -5/-6 site account for t...
ORGANISM(S): Mus musculus 
2013-03-06 | E-MTAB-890 | biostudies-arrayexpress
GenomicsCapStarr-seq: a high-throughput method for quantitative assessment of enhancer activity in mammals (ChIP-Seq)
Here we developed CapStarr-Seq, a novel high-throughput strategy to quantitatively assess enhancer activity in mammals. This approach couples capture of regions of interest to previously developed Starr-seq technique. Extensive assessment of CapStarr-seq demonstrated accurate quantification of enhan...
ORGANISM(S): Mus musculus 
2015-04-09 | E-GEOD-63732 | biostudies-arrayexpress
GenomicsCombinatorial transcription factor binding evolution in five placental mammals
Zoo-ChIP: Functional analysis of experimentally determined combinatorial transcription factor binding in multiple mammalian species
ORGANISM(S): Rattus norvegicus 
2014-09-27 | E-MTAB-1509 | biostudies-arrayexpress
GenomicsChIP-seq of Canis familiaris, Gallus gallus, Mus musculus, Homo sapiens, Monodelphis domestica to investigate CEBPA and HNF4a binding in five vertebrates
Five-vertebrate ChIP-seq reveals the evolutionary dynamics of trancription factor binding. The SRF files for this experiment can be found in the European Read Archive with study accession number ERP000054. The fastq files can be found in the raw archives and for some assays links to the ENA runs and...
ORGANISM(S): Canis familiaris 
2010-04-08 | E-TABM-722 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver with CEBPa wild type and knockout animals.
Expression analysis of CEBPa knockout effects on gene expression in adult mouse liver. We used a conditional knock out strategy to delete CEBPa specifically in adult mouse hepatocytes and analysed the resulting changes in gene expression by means of microarrays.
ORGANISM(S): Mus musculus 
2010-04-08 | E-MTAB-178 | biostudies-arrayexpress
UnknownEfficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico.
Not available
S-EPMC8693692 | biostudies-literature
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