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GenomicsHira-dependent histone H3.3 deposition facilitates PRC2 recruitment at developmental loci in ES cells [ChIP-Seq]
Polycomb repressive complex 2 (PRC2) regulates gene expression during lineage specification through trimethylation of lysine 27 on histone H3 (H3K27me3). In Drosophila, polycomb binding sites are dynamic chromatin regions coupled to incorporation of the histone variant H3.3. Here we show in mouse em...
ORGANISM(S): Mus musculus 
2013-09-30 | E-GEOD-42152 | biostudies-arrayexpress
TranscriptomicsHira-dependent histone H3.3 deposition facilitates PRC2 recruitment at developmental loci in ES cells [CATCH-IT]
Polycomb repressive complex 2 (PRC2) regulates gene expression during lineage specification through trimethylation of lysine 27 on histone H3 (H3K27me3). In Drosophila, polycomb binding sites are dynamic chromatin regions coupled to incorporation of the histone variant H3.3. Here we show in mouse em...
ORGANISM(S): Mus musculus 
2013-09-30 | E-GEOD-42153 | biostudies-arrayexpress
TranscriptomicsHira-dependent histone H3.3 deposition facilitates PRC2 recruitment at developmental loci in ES cells [RNA-Seq]
Polycomb repressive complex 2 (PRC2) regulates gene expression during lineage specification through trimethylation of lysine 27 on histone H3 (H3K27me3). In Drosophila, polycomb binding sites are dynamic chromatin regions coupled to incorporation of the histone variant H3.3. Here we show in mouse em...
ORGANISM(S): Mus musculus 
2013-09-30 | E-GEOD-42154 | biostudies-arrayexpress
TranscriptomicsHistone variant H3.3 is an essential maternal factor for oocyte reprogramming
Mature oocyte cytoplasm can reprogram somatic cell nuclei to the pluripotent state through a series of sequential events including protein exchange between the donor nucleus and ooplasm, chromatin remodeling, and pluripotency gene reactivation. Maternal factors that are responsible for this reprogra...
ORGANISM(S): Mus musculus 
2014-06-02 | E-GEOD-56762 | biostudies-arrayexpress
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