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TranscriptomicsLNCaP and C42B LSD1 knockdown microarray gene expression data and C42B androgen (DHT) stimulation microarray gene expression data
LSD1 (also known as KDM1A) is a histone demethylase and a key regulator of gene expression in embryonic stem cells and cancer. LSD1 was initially identified as a transcriptional repressor via its demethylation of active histone H3 marks (di-methyl lysine 4 [2MK4]). In prostate cancer, specifically, ...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-61630 | biostudies-arrayexpress
GenomicsLSD1 promotes castration-resistant prostate cancer progression
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-77763 | biostudies-arrayexpress
TranscriptomicsSCL005: icSARS CoV Urbani or icSARS deltaORF6 infections of the 2B4 clonal derivative of Calu-3 cells - Time course
Purpose of experiment was to compare transcriptomics of 2B4 cells (clonal derivative of Calu-3 cells) infected with either icSARS CoV or the icSARS deltaORF6 mutant. Calu-3 cells were infected with either icSARS CoV or the icSARS deltaORF6 mutant at MOI of 5.0. Cells samples were collected at 0, 3,...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-33267 | biostudies-arrayexpress
GenomicsLNCaP LSD1 knockdown and SP-2509 treatment ChIP-seq data
LSD1 (also known as KDM1A) is a histone demethylase and a key regulator of gene expression in embryonic stem cells and cancer.1,2 LSD1 was initially identified as a transcriptional repressor via its demethylation of active histone H3 marks (di-methyl lysine 4 [2MK4]).1 In prostate cancer, specifica...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-77762 | biostudies-arrayexpress
TranscriptomicsSCL006,icSARS CoV Urbani or icSARS Bat SRBD (spike receptor binding domain from the wild type strain Urbani to allow for infection of human and non-human primate cells) infections of the 2B4 clonal derivative of Calu-3 cells - Time course
Purpose of experiment was to compare transcriptomics of 2B4 cells (clonal derivative of Calu-3 cells) infected with either icSARS CoV or the icSARS deltaORF6 mutant. Calu-3 cells were infected with either icSARS CoV or the cSARS Bat SRBD strain at MOI of 1.0. Cells samples were collected at 0, 7, 1...
ORGANISM(S): Homo sapiens 
2012-05-06 | E-GEOD-37827 | biostudies-arrayexpress
TranscriptomicsHost Regulatory Network Response to Infection with Highly Pathogenic H5N1 Avian Influenza Virus
Over the last decade, more than half of humans infected with highly pathogenic avian influenza (HPAI) H5N1 viruses have died, and yet virus-induced host signaling has yet to be clearly elucidated. Airway epithelia are known to produce inflammatory mediators that contribute to HPAI H5N1-mediated pat...
ORGANISM(S): Homo sapiens 
2011-09-01 | E-GEOD-28166 | biostudies-arrayexpress
TranscriptomicsICL002: Time course of Calu-3 cells infected with Influenza A/VN/1203/04
Purpose of experiment was to perform transcriptomics on Calu- 3 cells infected with Influenza A/VN/1203/04. Calu-3 cells were infected with Influenza A/VN/1203/04, at MOI of 1.0. Cells samples were collected at 0, 3, 7, 12, 18, and 24 h post infection. Each infected sample was done in duplicate. (D...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-33142 | biostudies-arrayexpress
TranscriptomicsSM001: SARS CoV MA15 infection of C57Bl/6 mouse model – Data from 4 viral doses at 1, 2, 4 and 7 days post infection.
Purpose of experiment was to perform transcriptomic analysis on C57Bl/6 mice infected with different doses of SARS CoV MA15 at 4 different days post infection. Twenty-week-old C57BL/6 mice were infected by intranasal instillation of 10^2, 10^3, 10^4 or 10^5 PFU of SARS CoV MA15 in 50 µl of PBS or mo...
ORGANISM(S): Mus musculus 
2011-11-01 | E-GEOD-33266 | biostudies-arrayexpress
TranscriptomicsTCL001: Calu-3 cells treated with either IFN alpha or gamma
Purpose of experiment was to compare transcriptomics of Calu-3 cells treated with either INF alpha or gamma. Calu-3 cells were treated with 1000 Units/ml of INFa (Sigma I4276) or 500 Units/ml of IFN γ (Sigma I3265). Cells were collected for RNA isolation at 0, 3, 6, and 18 or 22 h post treatment. E...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-33264 | biostudies-arrayexpress
TranscriptomicsIM001: Influenza A/VN/1203/04 infection of C57Bl/6 mouse model - Data from 3 viral doses at 1, 2, 4 and 7 days post infection
Purpose of experiment was to perform transcriptomic analysis on C57Bl/6 mice infected with different doses of Influenza A/VN/1203/04 at 4 different days post infection. Twenty-week-old C57BL/6 mice were infected by intranasal instillation of 10^2, 10^3 or 10^4 PFU of VN1203 in 50 µl of PBS or mock-i...
ORGANISM(S): Mus musculus 
2011-11-01 | E-GEOD-33263 | biostudies-arrayexpress
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