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TranscriptomicsEpidermal differentiation: basal vs. suprabasal keratinocytes
In epidermal differentiation basal keratinocytes detach from the basement membrane, stop proliferating, and express a new set of structural proteins and enzymes, which results in an impermeable protein/lipid barrier that protects us. To define the transcriptional changes essential for this process, ...
ORGANISM(S): Homo sapiens 
2010-12-15 | E-GEOD-26059 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human epidermal keratinocytes treated with IL-1
Interleukin-1 is a proinflammatory and immunomodulatory cytokine that plays a crucial role in inflammatory diseases of the skin, including bacterial infections, bullous diseases, UV damage and especially psoriasis. To characterize the molecular effects of IL-1 in epidermis, we defined the transcript...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9120 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human epidermal keratinocytes treated with IFN-gamma reveals IFN-gamma suppressed the expression of over 100 genes responsible for cell cycle, DNA replication and RNA metabolism.
Cultured epidermal keratinocyte controls used for IFNg, TNFa and IL1 treatment. Interferon (IFN)-gamma, is a multifunctional, immunomodulatory cytokine with cell type-specific antiviral activities, particularly important in skin, where it is implicated in many diseases ranging from warts to psoriasi...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-440 | biostudies-arrayexpress
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