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ProteomicsProteome wide analysis of NRF2 activation
Multiple cancers regulate oxidative stress by activating the transcription factor NRF2 through mutation of its negative regulator KEAP1. NRF2 has been studied extensively in KEAP1-mutant cancers, however the role of this pathway in cancers with wildtype KEAP1 remains poorly understood. To answer thi...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD039027 | Pride
Non-small cell lung cancer Nrf2-keap1 pathway Reductive stress 
ProteomicsSystematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS sensing pathway
Multiple anticancer drugs have been proposed to cause cell death, in part, by increasing the steady-state levels of cellular reactive oxygen species (ROS). However, for most of these drugs exactly how the resultant ROS function and are sensed is poorly understood. It remains unclear which proteins t...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD041138 | Pride
Chermoresistance  redox signaling Ros  chemical proteomics  organelle signaling  chemotherapy 
ProteomicsAsymmetric Engagement of Dimeric CRL3KBTBD4 by the Molecular Glue UM171 Licenses Degradation of HDAC1/2 Complexes
UM171 is a potent small molecule agonist of ex vivo human hematopoietic stem cell (HSC) self-renewal, a process that is tightly controlled by epigenetic regulation. By co opting KBTBD4, a substrate receptor of the CULLIN3-RING E3 ubiquitin ligase complex, UM171 promotes the degradation of members ...
ORGANISM(S): Homo Sapiens 
2024-11-21 | MSV000096487 | MassIVE
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