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TranscriptomicsChromatin immunoprecipitation of liver tissue from humans, wild type mice and a Down syndrome mouse model containing human chromosome 21 to determine where genetic sequence or nuclear environment directs tissue specific-specific transcription factor binding
Homologous sets of transcription factors direct conserved tissue-specific transcription, yet transcription factor binding events diverge rapidly between closely related species. We used hepatocytes from a Down syndrome mouse model containing human chromosome 21 to determine whether human genetic se...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-TABM-474 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver tissue from humans, wild type mice and a Down syndrome mouse model containing human chromosome 21 to determine whether genetic sequence or nuclear enviornment directs tissue-specific transcription factor binding
Homologous sets of transcription factors direct conserved tissue-specific transcription, yet transcription factor binding events diverge rapidly between closely related species. We used hepatocytes from a Down syndrome mouse model containing human chromosome 21 (TC1) to determine whether human gene...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-TABM-473 | biostudies-arrayexpress
TranscriptomicsFunctional evidence that Drosha over-expression in cervical squamous cell carcinoma affects cell phenotype and microRNA profiles [mRNA]
Comparison of mRNA expression profiles in W12 Series 1 cervical ectokeratinocytes at passage number 22 versus 19 (during which time the cells gain an invasive phenotype) As these cells demonstrate gain of chromosome 5p during this time, mRNA expression profiling data interrogated for over-expressed ...
ORGANISM(S): Homo sapiens 
2011-05-25 | E-GEOD-26176 | biostudies-arrayexpress
TranscriptomicsRNA-seq of poly-A enriched total RNA of brain, liver, kidney, heart and skeletal muscle samples from frog
This experiment contains the Xenopus tropicalis subset of data from the experiment E-GEOD-41338 (http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-41338/). mRNA profiles of several organs (brain, liver, kidney, heart, skeletal muscle) in multiple vertebrate species (mouse, chicken, lizard, frog, ...
ORGANISM(S): Xenopus tropicalis 
2012-12-22 | E-MTAB-3726 | biostudies-arrayexpress
TranscriptomicsRNA-seq of poly-A enriched total RNA of brain, liver, kidney, heart and skeletal muscle samples from chicken
This experiment contains the Gallus gallus subset of data from the experiment E-GEOD-41338 (http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-41338/). mRNA profiles of several organs (brain, liver, kidney, heart, skeletal muscle) in multiple vertebrate species (mouse, chicken, lizard, frog, puffe...
ORGANISM(S): Gallus gallus 
2012-12-22 | E-MTAB-3724 | biostudies-arrayexpress
TranscriptomicsRNA-seq of poly-A enriched total RNA of brain, liver, kidney, heart and skeletal muscle samples from lizard
This experiment contains the Anolis carolinensis subset of data from the experiment E-GEOD-41338 (http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-41338/). mRNA profiles of several organs (brain, liver, kidney, heart, skeletal muscle) in multiple vertebrate species (mouse, chicken, lizard, frog,...
ORGANISM(S): Anolis carolinensis 
2012-12-22 | E-MTAB-3727 | biostudies-arrayexpress
TranscriptomicsRNA-seq of poly-A enriched total RNA of brain, liver, kidney, heart and skeletal muscle samples from mouse
This experiment contains the Mus musculus subset of data from the experiment E-GEOD-41338 (http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-41338/). mRNA profiles of several organs (brain, liver, kidney, heart, skeletal muscle) in multiple vertebrate species (mouse, chicken, lizard, frog, puffer...
ORGANISM(S): Mus musculus 
2012-12-22 | E-MTAB-3725 | biostudies-arrayexpress
TranscriptomicsRNA-seq of poly-A enriched total RNA of brain, liver, kidney, heart and skeletal muscle samples from pufferfish
This experiment contains the Tetraodon nigroviridis subset of data from the experiment E-GEOD-41338 (http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-41338/). mRNA profiles of several organs (brain, liver, kidney, heart, skeletal muscle) in multiple vertebrate species (mouse, chicken, lizard, fr...
ORGANISM(S): Tetraodon nigroviridis 
2012-12-22 | E-MTAB-3728 | biostudies-arrayexpress
TranscriptomicsRNA-seq of poly-A enriched total RNA of brain, liver, kidney, heart and skeletal muscle samples from 5 vertebrate species: mouse, chicken, frog, lizard and pufferfish
How species with similar repertoires of protein coding genes differ so dramatically at the phenotypic level is poorly understood. From comparing the transcriptomes of multiple organs from vertebrate species spanning ~350 million years of evolution, we observe significant differences in alternative s...
ORGANISM(S): Mus musculus 
2012-12-22 | E-GEOD-41338 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation profiling of human HeLa cells after immunoprecipitation of ptb65 associated mRNAs
PTB is multifunctional RNA binding protein reported to be involved in splicing, 3' -end processing, stability and translational regulation. Sample preparation methods (Gama-Carvalho et al, 2006, submitted); Suspension HeLa cells were grown in DMEM, 10% FCS, Pen/Strep and split 1:2 the day before har...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6021 | biostudies-arrayexpress
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