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TranscriptomicsMouse lung tissue transcriptome response to a mouse-adapted strain of SARS-CoV in wild type C57BL6/NJ mice and TLR3-/- mice
The purpose is to determine the role of TLR3-/- on the regulation of the host immune response during lethal SARS-CoV infection Groups of 10 week old C57BL6/NJ or TLR3-/- mice were infected with MA15 virus at a dose of 10^5 PFU or time-matched mock infected. Time points were 2, 4 and 7 days post in...
ORGANISM(S): Mus musculus 
2015-05-12 | E-GEOD-68820 | biostudies-arrayexpress
TranscriptomicsCell host-response to infection with novel human coronavirus EMC predict potential antivirals and important differences with SARS-coronavirus.
Differential expression was determined in Calu-3 cells between mock infected and infection with either Human coronavirus EMC and SARS coronavirus at different times post infection. Calu-3 2B4 cells were infected with Human Coronavirus EMC 2012 (HCoV-EMC) or mock infected. Samples were collected 0, ...
ORGANISM(S): Homo sapiens 
2013-05-03 | E-GEOD-45042 | biostudies-arrayexpress
TranscriptomicsCytokine stimulation systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates.
Background: The recent emergence of a novel coronavirus in the Middle East (designated MERS-CoV) is a reminder of the zoonotic potential of coronaviruses and the severe disease these etiologic agents can cause in humans. Clinical features of Middle East respiratory syndrome (MERS) include severe acu...
ORGANISM(S): Homo sapiens 
2014-08-31 | E-GEOD-56677 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of host response to mouse-adapted SARS virus in wild type, STAT1 -/-, and IFNAR1 -/- mouse genetic backgrounds
The mechanisms by which pulmonary lesions and fibrosis are generated during SARS-CoV infection are not known. Using high-throughput mRNA profiling, we examined the transcriptional response of wild-type (WT), type I interferon receptor knockout (IFNAR1−/−), and STAT1 knockout (STAT1−/−) mice infected...
ORGANISM(S): Mus musculus 
2012-02-22 | E-GEOD-36016 | biostudies-arrayexpress
TranscriptomicsSM001: SARS CoV MA15 infection of C57Bl/6 mouse model – Data from 4 viral doses at 1, 2, 4 and 7 days post infection.
Purpose of experiment was to perform transcriptomic analysis on C57Bl/6 mice infected with different doses of SARS CoV MA15 at 4 different days post infection. Twenty-week-old C57BL/6 mice were infected by intranasal instillation of 10^2, 10^3, 10^4 or 10^5 PFU of SARS CoV MA15 in 50 µl of PBS or mo...
ORGANISM(S): Mus musculus 
2011-11-01 | E-GEOD-33266 | biostudies-arrayexpress
TranscriptomicsSHAE004: SARS-CoV, SARS-dORF6 and SARS-BatSRBD infection of HAE cultures.
HAE cultures were infected with SARS-CoV, SARS-dORF6 or SARS-BatSRBD and were directly compared to A/CA/04/2009 H1N1 influenza-infected cultures. Cell samples were collected at various hours post-infection for analysis. Time Points = 0, 12, 24, 36, 48, 60, 72, 84 and 96 hrs post-infection for SARS-...
ORGANISM(S): Homo sapiens 
2013-07-31 | E-GEOD-47962 | biostudies-arrayexpress
TranscriptomicsSM015 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1a/1b knockouts
Comparing the host response of C57BL/6J mice to Tnfrsf1a/1b knockouts in the same strain of mice. Groups of 10-week-old C57BL/6 mice or Tnfrsf1a/1b knockout mice were infected with SARS MA15 at a dose of 10^5 PFU or mock infected. Mice were euthanized on days 4 and 7 post-infection to measure virus ...
ORGANISM(S): Mus musculus 
2012-09-13 | E-GEOD-40840 | biostudies-arrayexpress
TranscriptomicsSM007 - Infection with SARS MA15 of C57BL6/J mice and CXCR3 knockouts in the same strain of mice
The purpose of this experiment is to compare the host response of C57BL6/J mice to that of CXCR3 knockout mutant mice in response to SARS MA15 virus infections. Groups of 10 week old C57BL6 mice or CXCR3 knockout mice were infected with SARS MA15 at a dose of 10^5 PFU or mock infected. Mice were eut...
ORGANISM(S): Mus musculus 
2014-02-20 | E-GEOD-50878 | biostudies-arrayexpress
TranscriptomicsSM019 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1b knockout mice
Comparing the host response of C57BL/6J mice to Tnfrsf1b knockouts in the same strain of mice. Groups of 10-week-old C57BL/6 mice or Tnfrsf1a/1b knockout mice were infected with SARS MA15 at a dose of 10^5 PFU or mock infected. Mice were euthanized on days 4 and 7 post-infection to measure virus loa...
ORGANISM(S): Mus musculus 
2012-09-13 | E-GEOD-40824 | biostudies-arrayexpress
TranscriptomicsSCL005: icSARS CoV Urbani or icSARS deltaORF6 infections of the 2B4 clonal derivative of Calu-3 cells - Time course
Purpose of experiment was to compare transcriptomics of 2B4 cells (clonal derivative of Calu-3 cells) infected with either icSARS CoV or the icSARS deltaORF6 mutant. Calu-3 cells were infected with either icSARS CoV or the icSARS deltaORF6 mutant at MOI of 5.0. Cells samples were collected at 0, 3,...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-33267 | biostudies-arrayexpress
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