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TranscriptomicsEpstein Barr virus Nuclear Antigen 3C regulated genes in Lymphoblastoid Cell Lines
Epstein Barr virus (EBV) nuclear antigen 3C (EBNA3C) is an essential transcription factor for initiating and maintaining human B lymphocyte transformation to lymphoblastoid cell lines (LCLs). To comprehensively identify EBNA3C regulated cell genes in LCLs, oligonucleotide arrays were used to compare...
ORGANISM(S): Homo sapiens 
2011-01-06 | E-GEOD-24362 | biostudies-arrayexpress
GenomicsEpstein-Barr Virus oncoprotein super-enhancers control B cell growth
Super-enhancers are principal determinants of cell transcription, development, phenotype, and oncogenesis, not yet implicated in host-pathogen interactions. We found four Epstein-Barr virus (EBV) oncoproteins and five EBV-activated NF-M-oM-^AM-+B subunits co-occupying thousand of enhancer sites in E...
ORGANISM(S): Homo sapiens 
2014-11-01 | E-GEOD-62912 | biostudies-arrayexpress
TranscriptomicsCanonical NF-kB Activation is Essential for Epstein-Barr Virus Latent Membrane Protein 1 TES2/CTAR2 Gene Regulation.
Epstein-Barr Virus (EBV) Latent Membrane Protein 1 (LMP1) transforms rodent fibroblasts and is expressed in most EBV-associated malignancies. LMP1 Transformation Effector Site 2 (TES2)/C-Terminal Activation Region 2 (CTAR2) activates NF-kappaB, p38, JNK, ERK and IRF7 pathways. We have investigated L...
ORGANISM(S): Homo sapiens 
2011-05-15 | E-GEOD-29297 | biostudies-arrayexpress
UnknownStructural basis for T cell alloreactivity among three HLA-B14 and HLA-B27 antigens.
Not available
S-EPMC2785609 | biostudies-literature
ProteomicsPRMT1 inhibition induces differentiation of colon cancer cells
Colorectal cancer (CRC) is the third most commonly occurring cancer in men and the second most commonly occurring cancer in women, with over 1.8 million new cases in 20181. Differentiation therapy has been recently revisited as a prospective approach in cancer therapy2 by targeting the aberrant grow...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD016799 | Pride
Ms023 Pmrt1 inhibitors Colorectal cancer 
UnknownThe different epidemiologic subtypes of Burkitt lymphoma share a homogenous micro RNA profile distinct from diffuse large B-cell lymphoma.
Not available
S-EPMC3902789 | biostudies-literature
UnknownViral oncogene EBNALP regulates YY1 DNA binding and alters host 3D genome organization
Not available
S-SCDT-10_1038-S44319-024-00357-6 | biostudies-other
TranscriptomicsTranslating Dosage Compensation to Trisomy 21
Down syndrome is a common disorder with enormous medical and social costs, caused by trisomy for Chr21. We tested the concept that gene imbalance across an extra chromosome can be de facto corrected in DS patient stem cells by manipulating a single gene, XIST. Using zinc finger nucleases, we targete...
ORGANISM(S): Homo sapiens 
2013-07-12 | E-GEOD-47014 | biostudies-arrayexpress
TranscriptomicsSaccharomyces cerevisiae cells: control vs positive supercoiling accumulation after 0, 30 and 120 min
Positive DNA helical stress accumulates in vivo by the unbalanced relaxation of positive and negative DNA supercoils in Δtop1, top2ts, pGPD:TopA yeast cells. The resulting overwinding of DNA greatly diminishes overall RNA synthesis. Here we show that whereas most genes reduce their transcript level...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-19 | E-GEOD-18240 | biostudies-arrayexpress
GenomicsExome Sequencing for Diseases of the Immune System: X-linked Immunodeficiency with Magnesium Defect, EBV Infection, and Neoplasia (XMEN)

The etiologies of primary immunodeficiencies often yield novel insights about the immune system. Although a genetic etiology has been suspected for patients with abnormally low CD4+ T cells in the absence of HIV infection or any known causes of lymphopenia, no genetic mutation has been de...

phs000365.v1.p1 | EGA
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