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TranscriptomicsWidespread shortening of 3' untranslated regions and increased exon inclusion characterize the human macrophage response to infection
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-09-06 | E-GEOD-73765 | biostudies-arrayexpress
TranscriptomicsDeciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection.
Identification of genetic polymorphisms associated with inter-individual variation in immune response to Mycobacterium tuberculosis infection. We performed a genome-wide mapping study of loci that are associated with functional variation in immune response to MTB. Specifically, we characterized tran...
ORGANISM(S): Homo sapiens 
2011-12-06 | E-GEOD-34151 | biostudies-arrayexpress
TranscriptomicsGenetic ancestry and natural selection drive population differences in immune responses to pathogens in humans
Individuals from different populations vary considerably in their susceptibility to immune-related diseases. To understand how genetic variation and natural selection contribute to these differences, we tested for the effects of African versus European ancestry on the transcriptional response of pri...
ORGANISM(S): Homo sapiens 
2016-09-06 | E-GEOD-81046 | biostudies-arrayexpress
TranscriptomicsMycobacterial infection induces a specific human innate immune response
The innate immune system provides the first response to pathogen infection and orchestrates the activation of the adaptive immune system. Though a large component of the innate immune response is common to all infections, pathogen-specific innate immune responses have been documented as well. The in...
ORGANISM(S): Homo sapiens 
2015-03-31 | E-GEOD-67427 | biostudies-arrayexpress
Genomicse8e237ad-12b0-4a8b-b547-b5cfe0904955 - samples
Exome sequencing of 317 rainforest hunter-gatherers (RHG) and neighbouring farmers (AGR) from Central Africa was performed based on the Nextera Rapid Capture Expanded Exome Kit (62-Mb content) with the Illumina HiSeq 2500. The population sample includes the Baka of south-eastern Cameroon and norther...
EGAD00001004569 | EGA
GenomicsThe demographic history and mutational load of African hunter-gatherers and farmers
The distribution of deleterious genetic variation across human populations is a key issue in evolutionary biology and medical genetics. However, the impact of different modes of subsistence on recent changes in population size, patterns of gene flow, and deleterious mutational load remains unclear. ...
EGAS00001002457 | EGA
GenomicsGEH Data Access Committee
Data Access Committee EGAC00001000139
EGAC00001000139 | EGA
GenomicsGenome-wide SNP genotyping of Central African rainforest hunter-gatherers and neighbouring agriculturalists
The emergence of agriculture in West-Central Africa, ~5,000 years ago, profoundly modified the cultural landscape and mode of subsistence of most sub-Saharan populations. How this major innovation has impacted the genetic history of rainforest hunter-gatherers — historically referred to as “pygmies”...
EGAS00001000605 | EGA
GenomicsEvolution of the African pygmy phenotype
The evolutionary history of the human ‘pygmy’ phenotype (small body size), a characteristic of African and Southeast Asian rainforest hunter-gatherers, is largely unknown. Here we use a genome-wide admixture mapping analysis to identify 16 genomic regions that are significantly associated with the p...
EGAS00001000908 | EGA
GenomicsEvolution of the African pygmy phenotype
Data Access Committee EGAC00001000216
EGAC00001000216 | EGA
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