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TranscriptomicsChromatin immunoprecipitation of mouse and human cell lines and tissues using E2F4 antibodies
Despite being expressed in most tissues, a number of mammalian process-specific transcriptional regulators, such as those involved in cell cycle and immune responses, often have profound tissue-specific phenotypes. The mechanism underlying this effect is poorly understood. We chose to investigate ...
ORGANISM(S): Mus musculus 
2007-07-05 | E-TABM-272 | biostudies-arrayexpress
TranscriptomicsNext Generation RNAseq of neonatal hearts one day post surgery comparing sham, apical resection or apical resecection plus vagotomy treatments
We report global RNA expression profiles in whole heart ventricle tissue from postnatal day 2 mice that had undergone surgery 24 hours prior to collection. Retinal mRNA profiles of 21-day old wild type (WT) and Nrl-/- mice were generated by deep sequencing, in triplicate, using Illumina GAIIx.
ORGANISM(S): Mus musculus 
2015-06-16 | E-GEOD-69855 | biostudies-arrayexpress
TranscriptomicsSPECtre: a spectral coherence-based classifier of actively translated transcripts from ribosome profiling sequence data
Active protein translation can be assessed and measured using ribosome profiling sequencing strategies. Existing approaches make use of sequence fragment length or frame occupancy to differentiate between active translation and background noise, however they do not consider additional characteristic...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-75947 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Pdx1-GFP+ sorted E10.5, wildtype and Hes1-/-. Neurog3-dependent Pancreas Dysgenesis Causes Ectopic Pancreas in Hes1 Mutants
RNA-seq of FACS Sorted E10.5 Pdx1-GFP+ of genotypes wildtype and Hes1-/-. Summary statement The developmental mechanisms that cause ectopic pancreas are poorly understood. We show that aberrant dorsal pancreas morphogenesis in Hes1 mutants leads to ectopic pancreas depending on the pro-endocrine ge...
ORGANISM(S): Mus musculus 
2018-08-20 | E-MTAB-6890 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of liver tissue from humans, wild type mice and a Down syndrome mouse model containing human chromosome 21 to determine where genetic sequence or nuclear environment directs tissue specific-specific transcription factor binding
Homologous sets of transcription factors direct conserved tissue-specific transcription, yet transcription factor binding events diverge rapidly between closely related species. We used hepatocytes from a Down syndrome mouse model containing human chromosome 21 to determine whether human genetic se...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-TABM-474 | biostudies-arrayexpress
TranscriptomicsEuglycemic agent-mediated hypothalamic transcriptomic manipulation in the N171-82Q model of Huntington's disease is related to their physiological efficacy
Our aim was to find an effective treatment for the dysfunction in energy regulation and hypothalamic integrity occurring in many HuntingtonM-bM-^@M-^Ys disease (HD) patients and mouse models. HD is a neurodegenerative disease caused by an expanded CAG repeat and is characterized by mutant huntingtin...
ORGANISM(S): Mus musculus 
2012-10-05 | E-GEOD-39586 | biostudies-arrayexpress
TranscriptomicsAn arginine sensing pathway in Leishmania induces a Mitogen-Activated Protein Kinase 2-mediated response during macrophage invasion
Protozoa of the genus Leishmania are the causative agents of leishmaniasis in humans. These parasites cycle between promastigotes in the sand fly mid-gut and amastigotes in phagolysosome of mammalian macrophages. During infection, host up-regulate nitric oxide synthase and parasite induce host argin...
ORGANISM(S): Leishmania donovani 
2016-08-01 | E-GEOD-71572 | biostudies-arrayexpress
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