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TranscriptomicsChIP-chip of MG1655 with antibody against E. coli RNAP beta subunit under various conditions
We integrated RNAP binding regions (RBRs) and mRNA transcript abundance to determine segments of contiguous transcription originating from promoter regions. To measure RBRs at a genome scale, we employed a ChIP-chip method to E. coli K-12 MG1655 grown in the presence or absence of rifampicin under m...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2009-11-03 | E-GEOD-15588 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of E.coli MG1655 under multiple growth conditions
Investigation of comprehensive information about the expression level of RNA transcripts across the entire E.coli genome in mulitple growth conditions, including log-phase; stationary phase, heat shock and nitrogen-limiting condition. A fourteen chip study using total RNA recovered from four separa...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2009-11-03 | E-GEOD-15534 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat neonatal ventricular cardiomyocytes (NRVCMs) stretched biaxially (112%/24h) or stimulated with phenylephrine (PE, 50 uM
Neonatal rat ventricular cardiomyocytes (NRVCMs) were stretched biaxially (112%/24h) or stimulated with phenylephrine (PE, 50 uM), both resulting in a similar degree of hypertrophy. Unstretched NRVCMs served as negative control. Affymetrix microarray analysis revealed 164 genes more than 2.0-fold up...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-5996 | biostudies-arrayexpress
GenomicsHog1 controls global reallocation of RNA Pol II upon osmotic shock
When challenged with osmotic shock, S. cerevisiae induces hundreds of genes, despite a global reduction in transcriptional capacity. The mechanisms that regulate this rapid reallocation of transcriptional resources are not known. Here we show that redistribution of RNA Pol II upon stress requires ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-07-15 | E-GEOD-38208 | biostudies-arrayexpress
GenomicsChromatin accessibility maps of chronic lymphocytic leukemia identify subtype-specific epigenome signatures and transcription regulatory networks
Chronic lymphocytic leukemia (CLL) is characterized by substantial clinical heterogeneity, despite relatively few genetic alterations. To provide a basis for studying epigenome deregulation in CLL, we established genome-wide chromatin accessibility maps for 88 CLL samples from 55 patients using the ...
ORGANISM(S): Homo sapiens 
2016-06-26 | E-GEOD-81274 | biostudies-arrayexpress
TranscriptomicsDisruption of KCC2 in parvalbumin-positive interneurons causes fatal epilepsy in mice
Since many years, we are interested in the regulation of the intraneuronal chloride concentration. We were the first group reporting a full knockout of the KCl-co-transporter KCC2, which dies immediately after birth due to respiratory failure. Notably, KCC2 loss-of-function mutations are associated ...
ORGANISM(S): Mus musculus 
2022-11-02 | E-MTAB-11147 | biostudies-arrayexpress
UnknownCausal Pathways from Enteropathogens to Environmental Enteropathy: Findings from the MAL-ED Birth Cohort Study.
Not available
S-EPMC5405169 | biostudies-literature
GenomicsZEB1 in 3T3-L1 differentiation (ChIP-seq)
We aimed to characterise genome-wide ZEB1 binding pattern in 3T3-L1 cells at distinct timepoints of adipogenic differentiation (days -2, 0, 2 and 4). We performed replicate experiments at days -2 and 0 and single experiments at days 2 and 4.
ORGANISM(S): Mus musculus 
2014-09-17 | E-MTAB-2537 | biostudies-arrayexpress
TranscriptomicsThe activation potential of MOF is constrained for dosage compensation
The H4K16 acetyltransferase MOF plays a crucial role in dosage compensation in Drosophila, but has additional, global functions. We compared the molecular context and effect of MOF in male and female flies combining chromosome-wide mapping and transcriptome studies with analyses of defined reporter ...
ORGANISM(S): Drosophila melanogaster 
2010-06-26 | E-GEOD-20695 | biostudies-arrayexpress
UnknownIntestinal permeability and inflammation mediate the association between nutrient density of complementary foods and biochemical measures of micronutrient status in young children: results from the MAL-ED study.
Not available
S-EPMC6766446 | biostudies-literature
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