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TranscriptomicsBile acids promote adenocarcinoma in a novel transgenic mouse model of BarrettM-bM-^@M-^Ys esophagus
Esophageal adenocarcinoma (EAC) has the fastest increase of any cancer in the US and Europe, and arises in the setting of BarrettM-bM-^@M-^Ys esophagus (BE), defined by replacement of normal squamous epithelium with columnar intestinal-like epithelium. BE is thought to result from chronic esophagea...
ORGANISM(S): Mus musculus 
2011-01-31 | E-GEOD-24931 | biostudies-arrayexpress
MetabolomicsMechanistic insights into the biological activity of S-Sulfocysteine in CHO cells using a multi-omics approach
S-Sulfocysteine (SSC), a bioavailable L-cysteine derivative (Cys), is known to be taken up and metabolized in Chinese hamster ovary (CHO) cells used to produce novel therapeutic biological entities. To gain a deeper mechanistic insight into the SSC biological activity and metabolization, a multi-omi...
2024-08-08 | MTBLS7424 | MetaboLights
MetabolomicsMetabolomic analysis of alfalfa (Medicago sativa L.) root-symbiotic rhizobia responses under alkali stress
Alkaline salts (e.g., NaHCO3 and Na2CO3) causes more severe morphological and physiological damage to plants than neutral salts (e.g., NaCl and Na2SO4) due to differences in pH. The mechanism by which plants respond to alkali stress is not fully understood, especially in plants having symbotic relat...
2018-07-27 | MTBLS481 | MetaboLights
TranscriptomicsFUNCTIONAL ANALYSIS OF CTCF DURING MAMMALIAN LIMB DEVELOPMENT_ ChIP-chip
Limb buds were dissected from E10.75 mouse embryos, fixed in 1% formaldehyde for 15 min at room temperature, washed 3 times with cold PBS and stored at -800C. Pools of 16 limb buds were used for each ChIP-chip experiment. ChIP was performed according to (Lee et al., 2006) using 2 ?g of anti-CTCF ant...
ORGANISM(S): Mus musculus 
2011-11-01 | E-MEXP-2979 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of E. coli response to 0.2 mM Zn
E. coli response to 0.2 mM Zn
ORGANISM(S): Escherichia coli 
2005-03-01 | E-MEXP-222 | biostudies-arrayexpress
TranscriptomicsAlteration of gene expression in MCF-7 cells induced by king cobra venom L-amino acid oxidase (OH-LAAO)
Alteration of gene expression in MCF-7 cells using array-based whole genome gene expression technology . Results provide useful information on the molecular events leading to cell death induced by L-amino acid oxidase enzyme. MCF-7 cells were treated with IC20 value of OH-LAAO or PBS (control). Trea...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-59382 | biostudies-arrayexpress
ProteomicsAKT Inhibition Promotes Non-autonomous Cancer Cell Survival [Antibody Arrays (L-507)]
Small-molecule inhibitors of AKT signaling are being in evaluated in patients with various cancer types, but have so far proven therapeutically disappointing for reasons that remain unclear. Here, we treat cancer cells with sub-therapeutic doses of Akti-1/2, an allosteric small molecule AKT inhibito...
ORGANISM(S): Homo sapiens 
2015-12-09 | E-GEOD-71892 | biostudies-arrayexpress
ProteomicsAKT Inhibition Promotes Non-autonomous Cancer Cell Survival [Antibody Arrays (L-493)]
Small-molecule inhibitors of AKT signaling are being in evaluated in patients with various cancer types, but have so far proven therapeutically disappointing for reasons that remain unclear. Here, we treat cancer cells with sub-therapeutic doses of Akti-1/2, an allosteric small molecule AKT inhibito...
ORGANISM(S): Homo sapiens 
2015-12-09 | E-GEOD-71891 | biostudies-arrayexpress
TranscriptomicsThe ability of VSL#3 to restore the age-related deficit in LTP is associated with changes in brain genes expression
A deficit in synaptic plasticity is one of the many changes that occurs with age. Specifically the archetypal model of plasticity, long-term potentiation (LTP), is reduced in hippocampus of middle-aged and aged animals. Several factors are likely to contribute to this deficit including morphologic...
ORGANISM(S): Rattus norvegicus 
2014-04-02 | E-GEOD-51381 | biostudies-arrayexpress
UnknownDevelopment and Validation of Nomograms Predictive of Overall and Progression-Free Survival in Patients With Oropharyngeal Cancer.
Not available
S-EPMC5736236 | biostudies-literature
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