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TranscriptomicsRNAseq of tumor samples from CT26 syngeneic mouse treated with a PD-L1 and CTLA-4 immunotherapy combination
The ability to modulate immune-inhibitory pathways using checkpoint blockade antibodies such as PD-1, PD-L1, and CTLA-4 represents a significant breakthrough in cancer therapy in recent years. This has driven interest in identifying small-molecule-immunotherapy combinations to increase the proportio...
ORGANISM(S): Mus musculus 
2020-04-16 | E-MTAB-7777 | biostudies-arrayexpress
TranscriptomicsRNAseq of tumor samples from CT26 syngeneic mouse treated with a PI3Ka/d inhibitor (AZD8835)
PI3K inhibitors with differential selectivity to distinct PI3K isoforms have been tested extensively in clinical trials, largely to target tumor epithelial cells. PI3K signaling also regulates the immune system and inhibition of PI3Kdelta modulate the tumor immune microenvironment of pre-clinical mo...
ORGANISM(S): Mus musculus 
2019-01-08 | E-MTAB-7386 | biostudies-arrayexpress
TranscriptomicsExpression profiling of murine hemopoietic cell survival on oligo arrays.
Deregulated cell survival programs are a classical hallmark of cancer. We have previously identified a serine residue (Ser585) in the beta-c subunit of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor that selectively and independently promotes cell survival. We now show that S...
ORGANISM(S): Mus musculus 
2010-05-22 | E-GEOD-18220 | biostudies-arrayexpress
TranscriptomicsExpression profiling of murine hemopoietic cell survival on cDNA arrays.
Deregulated cell survival programs are a classical hallmark of cancer. We have previously identified a serine residue (Ser585) in the beta-c subunit of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor that selectively and independently promotes cell survival. We now show that S...
ORGANISM(S): Mus musculus 
2010-05-22 | E-GEOD-18221 | biostudies-arrayexpress
TranscriptomicsA genome-wide expression comparison of productive and unproductive airway epithelial repair
Defective epithelial repair in the setting of chronic lung disease has been suggested to contribute to uncontrolled extracellular matrix (ECM) deposition and development of fibrosis. We sought to directly test this hypothesis through gene expression profiling of total lung RNA isolated from mouse mo...
ORGANISM(S): Mus musculus 
2009-08-18 | E-GEOD-17693 | biostudies-arrayexpress
TranscriptomicsRNAseq profiling of tumor, tumor-draining-lymph nodes, blood and tumor-associated macrophages of MC38 mice treated with the PI3Kg inhibitor AZD3458 and a combination of AZD3458 and anti-PD-1
RNAseq profiling of AZD3458 monotherapy and combination treatment with anti-PD-1 of whole tumors, isolated tumor macrophages (Mac) (CD45+CD11b+F4/80+), whole blood (PB) and tumor draining lymph nodes (TDLN) were assessed to elucidate further mechanisms leading to enhanced combination activity.
ORGANISM(S): Mus musculus 
2021-02-28 | E-MTAB-10057 | biostudies-arrayexpress
TranscriptomicsExpression profiling of murine hemopoietic cell survival
This SuperSeries is composed of the following subset Series: GSE18220: Expression profiling of murine hemopoietic cell survival on oligo arrays. GSE18221: Expression profiling of murine hemopoietic cell survival on cDNA arrays. Refer to individual Series
ORGANISM(S): Mus musculus 
2010-05-22 | E-GEOD-18222 | biostudies-arrayexpress
GenomicGWAS of Preterm Birth

Preterm birth (PTB, born before 37 weeks of gestation) is a leading cause of neonatal mortality and post-natal morbidity. PTB affects one in nine all live births in the U.S. Notably, the highest rate of PTB occurs among African Americans (one in six). PTB is a complex trait, likely determined by ...

phs000332 | dbGaP
UnknownThe Political Consequences of Latino Prejudice against Blacks.
Not available
S-EPMC4888580 | biostudies-literature
TranscriptomicsRNA-seq of the prototrophic non-hyphal smooth-33 mutant (FKP514) and its prototrophic control strain (FKP391)
FKP503 is a non-hyphal mutant strain (smooth-33) that was obtained from multiple passages of its parental strain FKP355. FKP355 and FKP503 are leucine auxotrophic strains: for further investigation prototropic strains FKP391 and FKP514 were constructed. To compare transcriptomic changes, FKP391 and ...
ORGANISM(S): Yarrowia lipolytica 
2018-11-26 | E-MTAB-7400 | biostudies-arrayexpress
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