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TranscriptomicsTelomerase is a prognostic marker of poor outcome and a therapeutic target in neuroblastoma
The aim of this study is to determine the clinical relevance of telomerase activation versus ALT as biomarkers in pre-treatment neuroblastoma, and to assess the potential value of telomerase as a therapeutic target. Therefore, the genomic status of TERT and MYCN was assessed in 457 pretreatment neur...
ORGANISM(S): Homo sapiens 
2019-09-16 | E-MTAB-8248 | biostudies-arrayexpress
TranscriptomicsSNP array analysis of seven tumor cell lines carrying MYC amplifications
In order to clarify the mechanism to MYC (8q24) amplification as dmin or hsr, we finely investigated the organization of amplicons in seven tumor cell lines [four SCLC, one AML, and two Colon Carcinoma (CC)] by integrating next-generation sequencing (NGS), Fluorescent in situ hybridization (FISH), P...
ORGANISM(S): Homo sapiens 
2014-05-13 | E-MTAB-2248 | biostudies-arrayexpress
TranscriptomicsInfection exposure promotes ETV6-RUNX1 precursor B cell leukemia revealing secondary genomic alterations in histone modification genes
We used microarrays to investigate gene expression changes in ETV6/RUNX1 proB and preB cells Bone marrow proB and preB cells of four ETV6/RUNX1 mice compared with bone marrow proB and preB cells of three WT mice and three Pax5+/- mice.
ORGANISM(S): Mus musculus 
2015-07-03 | E-GEOD-70492 | biostudies-arrayexpress
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