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TranscriptomicsImprinting RNAseq
Long-term hematopoietic stem cells (HSCs), short-term HSCs and multipotent progenitor cells (MPPs) were isolated from bone marrow of four mouse strains (WT, H19-deletion, Igf1r-deletion, and double-deletion) and expression profiled with RNAseq. The behavior of the transcriptomes, and in particular...
ORGANISM(S): Mus musculus 
2013-08-12 | E-MTAB-1628 | biostudies-arrayexpress
TranscriptomicsDifferences in CTCF binding site sequence are associated with unique regulatory and functional trends during embryonic stem cell differentiation [RNA-Seq]
CTCF (CCCTC-binding factor) is a highly conserved 11-zinc finger DNA binding protein with tens of thousands of binding sites genome-wide. CTCF acts as a multifunctional regulator of transcription, having been previously associated with activator, repressor, and insulator activity. These diverse regu...
ORGANISM(S): Mus musculus 
2013-10-11 | E-GEOD-39522 | biostudies-arrayexpress
GenomicsDifferences in CTCF binding site sequence are associated with unique regulatory and functional trends during embryonic stem cell differentiation [ChIP-Seq]
CTCF (CCCTC-binding factor) is a highly conserved 11-zinc finger DNA binding protein with tens of thousands of binding sites genome-wide. CTCF acts as a multifunctional regulator of transcription, having been previously associated with activator, repressor, and insulator activity. These diverse regu...
ORGANISM(S): Mus musculus 
2013-10-11 | E-GEOD-39502 | biostudies-arrayexpress
TranscriptomicsFertile offspring derived from mouse spermatogonial stem cells cryopreserved for more than 14 years
To evaluate the possible deleterious affects prolonged cryopreservation and assisted reproductive technologies may have on the DNA of F0 progeny, we used array-based comparative genomic hybridization (CGH) for analysis of genomic DNA. ICSI-derived progeny were generated from ♂ (ZFLacZ sperm) x ♀ (DB...
ORGANISM(S): Mus musculus 
2012-01-13 | E-GEOD-35056 | biostudies-arrayexpress
TranscriptomicsA Novel Approach Identifies New Differentially Methylated Regions (DMRs) Associated with Imprinted Genes
Imprinted genes are critical for normal human growth and neurodevelopment. We developed a strategy to identify new DNA differentially methylated regions (DMRs), a hallmark of imprinted genes. Using genome-wide methylation profiling, candidate DMRs were selected by identifying CpGs with putative alle...
ORGANISM(S): Homo sapiens 
2011-01-26 | E-GEOD-22091 | biostudies-arrayexpress
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