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UnknownExpert consensus on vitamin D in osteoporosis.

Background

Adequate vitamin D is essential for maintaining optimal bone health, preventing and treating of osteoporosis. However, in recent years, large clinical trials and meta-analyses on the efficacy of vitamin D supplementation to prevent fractures in populations at different risks have ...
S-EPMC11836767 | biostudies-literature
UnknownIncorporating Concomitant Medications into Genome-Wide Analyses for the Study of Complex Disease and Drug Response.
Given the high costs of conducting a drug-response trial, researchers are now aiming to use retrospective analyses to conduct genome-wide association studies (GWAS) to identify underlying genetic contributions to drug-response variation. To prevent confounding results from a GWAS to investigate drug...
S-EPMC5013254 | biostudies-literature
UnknownEffect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial.

Background

Hyperglycaemia is associated with increased risk of cardiovascular complications in people with type 2 diabetes. We investigated whether reduction of blood glucose concentration decreases the rate of microvascular complications in people with type 2 diabetes.

Methods

ACCORD...
S-EPMC4123233 | biostudies-literature
UnknownEffects of combination lipid therapy in type 2 diabetes mellitus.

Background

We investigated whether combination therapy with a statin plus a fibrate, as compared with statin monotherapy, would reduce the risk of cardiovascular disease in patients with type 2 diabetes mellitus who were at high risk for cardiovascular disease.

Methods

We randomly ass...
S-EPMC2879499 | biostudies-literature
UnknownEffects of intensive blood-pressure control in type 2 diabetes mellitus.

Background

There is no evidence from randomized trials to support a strategy of lowering systolic blood pressure below 135 to 140 mm Hg in persons with type 2 diabetes mellitus. We investigated whether therapy targeting normal systolic pressure (i.e., <120 mm Hg) reduces major cardiovascular...
S-EPMC4123215 | biostudies-literature
UnknownLong-term effects of intensive glucose lowering on cardiovascular outcomes.

Background

Intensive glucose lowering has previously been shown to increase mortality among persons with advanced type 2 diabetes and a high risk of cardiovascular disease. This report describes the 5-year outcomes of a mean of 3.7 years of intensive glucose lowering on mortality and key car...
S-EPMC4083508 | biostudies-literature
UnknownEffects of intensive glucose lowering in type 2 diabetes.

Background

Epidemiologic studies have shown a relationship between glycated hemoglobin levels and cardiovascular events in patients with type 2 diabetes. We investigated whether intensive therapy to target normal glycated hemoglobin levels would reduce cardiovascular events in patients with ...
S-EPMC4551392 | biostudies-literature
UnknownEffects of medical therapies on retinopathy progression in type 2 diabetes.

Background

We investigated whether intensive glycemic control, combination therapy for dyslipidemia, and intensive blood-pressure control would limit the progression of diabetic retinopathy in persons with type 2 diabetes. Previous data suggest that these systemic factors may be important in...
S-EPMC4026164 | biostudies-literature
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