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MetabolomicsHuman basal cell carcinoma samples analysed by laser desorption rapid evaporative ionisation mass spectrometry (LD-REIMS) imaging

Laser ablation rapid evaporative ionisation mass spectrometry (LA-REIMS) was used to analyse human basal cell carcinoma (BCC) samples. 14 samples are presented here, along with H&E-stained histological images.

2025-07-28 | MTBLS12786 | MetaboLights
TranscriptomicsLong-noncoding RNAs in basal cell carcinoma
A total of 3 patients with basal cell carcinoma (BCC) and 3 healthy individuals (control; non-lesional skin) were enrolled in the study. Punch biopsies (4 mm) were obtained under local anaesthesia and immediately put in RNAlater (Qiagen, Hilden, Germany) and stored at - 80 °C until RNA extraction. ...
ORGANISM(S): Homo sapiens 
2016-03-29 | E-GEOD-74858 | biostudies-arrayexpress
TranscriptomicsFibroblasts prepared from stroma of basal cell carcinoma in comparison to normal dermal fibroblasts
Adult tissue stem cells are known to participate in cancer formation. Indeed, cells exhibiting markers of embryonic stem cells such as Oct-4 and Nanog were detected in some malignant tumors. In this study we demonstrated that stromal cells prepared from the basal cell carcinoma are able to induce ex...
ORGANISM(S): Homo sapiens 
2011-11-02 | E-MTAB-272 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of microRNA expression in basal cell carcinoma
Perturbations in the expression profiles of microRNAs (miRNAs) have been reported for a variety of different cancers. Basal cell carcinoma (BCC) of the skin has not been systematically evaluated regarding differentially expressed miRNAs. Patients with BCC (n=7) were included in the study. Punch biop...
ORGANISM(S): Homo sapiens 
2012-04-30 | E-GEOD-34535 | biostudies-arrayexpress
MetabolomicsStable Isotope-Assisted Metabolomics for Deciphering Xenobiotic Metabolism in Mammalian Cell Culture
Xenobiotics are ubiquitous in the environment and modified abundantly in the human body by phase I and II metabolism. Liquid chromatography coupled to high resolution mass spectrometry is a powerful tool to investigate these biotransformation products. Here, we present a workflow based on stable iso...
2020-04-14 | MTBLS1358 | MetaboLights
TranscriptomicsCorrelation of global micro RNA expression with basal cell carcinoma subtype
Basal cell carcinomas (BCCs) are the most common cancers in the US. Histologic appearance distinguishes several subtypes, each of which can have a different biologic behavior. In this study global miRNA expression was quantified by high throughput sequencing in nodular BCCs, a subtype that is slow...
ORGANISM(S): Homo sapiens 
2012-02-01 | E-GEOD-33665 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human nevoid basal cell carcinoma syndrome primary fibroblasts with non-sense or miss-sense mutations in the tumor supressor gene PTCH1
Mutations in the tumor suppressor gene PTCH1 are responsible for Gorlin syndrome, or nevoid basal cell carcinoma syndrome (NBCCS). NBCCS causes predisposition to basal cell carcinoma (BCC), the commonest cancer in adult human. In the general population BCC develop almost exclusively in sun-exposed a...
ORGANISM(S): Homo sapiens 
2009-03-19 | E-TABM-549 | biostudies-arrayexpress
TranscriptomicsBasal Cell Carcinoma Tumor-derived Fibroblasts
Dataset contains samples that are all fibroblast cells that have been cultured from fresh human tissue. Fibroblasts were derived either from tumor (basal cell carcinoma) or non-tumor (control) tissue. Samples were maintained in DMEM, 10% FBS, glutamine, pen/strep and passaged for 4 passages before...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-5502 | biostudies-arrayexpress
TranscriptomicsImiquimod treated Basal Cell Carcinoma
Imiquimod is a Toll-like receptor (TLR)-7 agonist capable of inducing complete clearance of basal cell carcinoma (BCC) and other cutaneous malignancies. We hypothesized that the characterization of the early transcriptional events induced by imiquimod may provide insights about immunological events ...
ORGANISM(S): Homo sapiens 
2006-10-04 | E-GEOD-5121 | biostudies-arrayexpress
TranscriptomicsMultiscale spatial mapping of cell populations across anatomical sites in healthy human skin and basal cell carcinoma - Spatial Transcriptomics - 10X Visium
Our understanding of how human skin cells differ according to anatomical site and tumour formation is limited. To address this we have created a multi-scale spatial atlas of healthy skin and basal cell carcinoma (BCC), incorporating in vivo optical coherence tomography, single cell RNA sequencing, s...
ORGANISM(S): Homo sapiens 
2023-12-22 | E-MTAB-13085 | biostudies-arrayexpress
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