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MetabolomicsSARS-CoV-2 ORF7a Drives Mitochondrial Dysfunction via PDK4 Activation and Complex I Inhibition

SARS-CoV-2 reprograms host metabolism to promote viral replication and evade immune responses. While infection is known to impair mitochondrial function and enhance glycolysis, the role of viral accessory proteins in these alterations remains unclear. Here, we investigate the metabolic impact of ...

2026-07-09 | MTBLS13338 | MetaboLights
ProteomicsProximity biotinylation of the Toxoplasma gondii basal complex
During T. gondii cell division (endodyogeny) the basal complex acts as the cytokinetic ring by preserving daughter bud integrity and executing the tapering and basal constriction of nascent parasites. Its molecular composition, order of assembly and mode of action are incompletely understood but dif...
ORGANISM(S): Toxoplasma gondii RH 
2022-08-09 | PXD031116 | Pride
Toxoplasma Basal complex Bioid 
TranscriptomicsTranscription profiling of human basal-like breast cancer - in vitro and in vivo Analysis of B-Myb
The basal-like breast cancer subtype portends a poor clinical prognosis, and a defining feature of this subtype is the high expression of genes in the “proliferation signature”. B-Myb, a member of the MYB protein family of transcription factors, is highly expressed in the proliferation signatur...
ORGANISM(S): Homo sapiens 
2009-01-18 | E-GEOD-11429 | biostudies-arrayexpress
TranscriptomicsThe Human Airway Epithelial Basal Cell Transcriptome
Background. The human airway epithelium consists of 4 major cell types: ciliated, secretory, columnar and basal cells. During natural turnover and in response to injury, the airway basal cells function as stem / progenitor cells for the other airway cell types. The objective of this study is to bett...
ORGANISM(S): Homo sapiens 
2011-06-10 | E-GEOD-24337 | biostudies-arrayexpress
TranscriptomicsMycobacterium tuberculosis Complex Clinical Isolates exhibit unique gene expression profiles in vitro and inside macrophages
This SuperSeries is composed of the following subset Series: GSE21111: Basal in vitro transcriptomes of Mycobacterium tuberculosis complex (MTC) clinical isolates GSE21112: Intracellular transcriptional adaptation of Mycobacterium tuberculosis complex (MTC) clinical isolates inside resting murine ma...
ORGANISM(S): Mycobacterium tuberculosis 
2010-07-09 | E-GEOD-21114 | biostudies-arrayexpress
TranscriptomicsMethylphenidate exposure induces dopamine neuron loss and activation of microglia in the basal ganglia of mice
Background: Methylphenidate (MPH) a psychostimulant prescribed to manage ADHD symptoms, has been increasingly prescribed to children not meeting the strict criteria for ADHD. It has also been misused as a “cognitive enhancer” and as an alternative to other psychostimulants. Here, we investigate whet...
ORGANISM(S): Mus musculus 
2012-08-13 | E-GEOD-33619 | biostudies-arrayexpress
TranscriptomicsLunatic Fringe Deficiency Cooperates with the Met/Caveolin Gene Amplicon to Induce Basal-Like Breast Cancer
SUMMARY: Basal breast cancer has been associated with mutations in a number of specific tumor suppressor genes, however, the mechanism by which these tumors express a basal lineage remains unknown. Notch signaling suppresses mammary stem cell (MaSC) self-renewal, while promoting luminal cell fate s...
ORGANISM(S): Mus musculus 
2012-05-29 | E-GEOD-28712 | biostudies-arrayexpress
TranscriptomicsBasal in vitro transcriptomes of Mycobacterium tuberculosis complex (MTC) clinical isolates
This study uses microarray analyses to examine baseline gene expression profiles for Mycobacterium tuberculosis complex clinical isolates relative to reference strain CDC1551 during log phase growth in vitro in 7H9 broth. For this in vitro analyses, log-phase mycobacteria in starter cultures grown t...
ORGANISM(S): Mycobacterium tuberculosis 
2010-07-08 | E-GEOD-21111 | biostudies-arrayexpress
TranscriptomicsBasal Cell Carcinoma Tumor-derived Fibroblasts
Dataset contains samples that are all fibroblast cells that have been cultured from fresh human tissue. Fibroblasts were derived either from tumor (basal cell carcinoma) or non-tumor (control) tissue. Samples were maintained in DMEM, 10% FBS, glutamine, pen/strep and passaged for 4 passages before...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-5502 | biostudies-arrayexpress
GenomicsPolycomb Repressive Complex 2 regulates basal cell fate during adult olfactory neurogenesis [EEDKO_H3K27me3_ChIP]
Polycomb Repressive Complex 2 regulates basal cell fate during adult olfactory neurogenesis [EEDKO_H3K27me3_ChIP]
PRJNA982161 | ENA
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