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UnknownPIK3CA mutations are associated with decreased benefit to neoadjuvant human epidermal growth factor receptor 2-targeted therapies in breast cancer.
Not available
S-EPMC5087318 | biostudies-literature
UnknownAdo-Trastuzumab Emtansine for Patients With HER2-Mutant Lung Cancers: Results From a Phase II Basket Trial.
Not available
S-EPMC6366814 | biostudies-literature
UnknownBRAF Inhibition in BRAFV600-Mutant Gliomas: Results From the VE-BASKET Study.
Not available
S-EPMC6286161 | biostudies-literature
TranscriptomicsPI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer
Activating mutations of PIK3CA are the most frequent genomic alterations in estrogen receptor (ER)-positive breast tumors and selective PI3Kα inhibitors are in clinical development. The activity of these agents, however, is not homogenous and only a fraction of patients bearing PIK3CA-mutant ER-posi...
ORGANISM(S): Homo sapiens 
2015-04-29 | E-GEOD-64033 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human glioma cells treated with TGF-beta or an inhibitor of the TGF-beta Receptor I LY2109761
In order to identify the genes that are regulated by TGF-beta in glioma, we serum starved two glioma cell lines, U373MG and U87MG, for 16h and we treated them with vehicle,100pM TGF-beta, 2uM inhibitor of the TGF-beta Receptor I(TbRI)(LY2109761), or both 100pM TGF-beta plus 2uM TbRI for 3h. Then, ce...
ORGANISM(S): Homo sapiens 
2007-05-16 | E-MEXP-903 | biostudies-arrayexpress
UnknownHER2DX ERBB2 mRNA expression in advanced HER2-positive breast cancer treated with T-DM1.
Not available
S-EPMC9996199 | biostudies-literature
TranscriptomicsCirculating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Cell Composition
By applying RNA-ISH and RNAseq to circulating tumor cells (CTCs), the study provides definitive evidence of epithelial to mesenchymal transition (EMT) across all histological types of breast cancer, identifying mediators such as FOXC1 and TGF-β signaling, and demonstrating dynamic treatment-associat...
ORGANISM(S): Homo sapiens 
2013-02-01 | E-GEOD-41245 | biostudies-arrayexpress
Genomicsena-DATASET-CRUK-CI-15-09-2016-11:30:35:546-51 - samples
Breast cancer PDTX sequencing data from Bruna et al, Cell 2016 - Exome Sequencing - Shallow Whole Genome Sequencing - RRBS Methylation Sequencing
EGAD00001002685 | EGA
Genomicsena-DATASET-CRUK-CI-22-07-2020-08:24:26:904-1617 - samples
RNA-SEQ for the Caldas Lab breast cancer PDTX collection. This includes both single and paired end runs
EGAD00001006307 | EGA
GenomicsExpressionPDTX
RNA Expression using Illumina HT12 v3
EGAD00010001032 | EGA
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