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TranscriptomicsCooperative blockade of CK2 and ATM kinases drives apoptosis in VHL-deficient renal carcinoma cells / RNA-seq (BRB-seq) of treated 786-O spheroids
Multicellular Tumor Spheroids (MCTS) were pre-formed for 3 days with 786-O cell line to better mimic the tumor microenviroenment. These spheroids were treated with either vehicle (DMSO), drugs alone (KU-60019 10 μM; CX-4945 5 μM) or in combination (KU + CX) for 48h before RNA extraction.
ORGANISM(S): Homo sapiens 
2021-02-04 | E-MTAB-9977 | biostudies-arrayexpress
TranscriptomicsTotal RNA sequencing for Mus musculus bone marrow lymphoid committed cell populations
MPP2, MPP3 and CLP populations were isolated by fluorescence-activated cell sorting (FACS) from the BM of B6 mice based on the surface expression of VCAM1, FLT3 and IL7Ra within LSK population. On average 100K cells were analyzed for each population in 3 independent biological experiments. We gene...
ORGANISM(S): Mus musculus 
2022-11-19 | E-MTAB-11217 | biostudies-arrayexpress
TranscriptomicsBRBseq performed on 786-O cells treated with 2 inhibitors of protein kinase CK2, CX4945 and AB668
786-O cells (150, 000) were treated for 24h with DMSO, 5 µM of CX4945 or AB668. Total RNA was extracted from treated cells using the MirVana PARIS kit (Thermofisher). The 3′ Bulk RNA Barcoding and sequencing (BRB-seq) experiments were performed at the Research Institute for Environmental and Occupat...
ORGANISM(S): Homo sapiens 
2023-05-27 | E-MTAB-12776 | biostudies-arrayexpress
TranscriptomicsBRBseq performed on tumoroids and corresponding renal tumor tissues
To evaluate genetic similarities between tumoroids and the corresponding tumor tissues, we performed RNA sequencing of cells for each experimental condition. Since we injected human cancer cells into mice, cancer cells in the tumors were human while microenvironmental cells (i.e. Fibroblasts, Immune...
ORGANISM(S): Homo sapiens 
2023-06-30 | E-MTAB-12928 | biostudies-arrayexpress
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