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TranscriptomicsEHMT1 and EHMT2 inhibition induce fetal hemoglobin expression [RNA-seq]
Using UNC0638 and genetic assays to inhibit EHMT1/2 and derepress fetal hemoglobin in adult hematopoietic cells. RNA-Seq in primary adult human erythroid cells treated with UNC0638 or the vehicle control (DMSO) in biological triplicates.
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-71421 | biostudies-arrayexpress
GenomicsEHMT1 and EHMT2 inhibition induce fetal hemoglobin expression [ChIP-seq]
Using UNC0638 and genetic assays to inhibit EHMT1/2 and derepress fetal hemoglobin in adult hematopoietic cells. ChIP-seq for 2 histone modifications and total H3 (for quantitative normalization) in biological triplicates of cord blood, adult bone marrow, and UNC0638-treated adult bone marrow.
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-69516 | biostudies-arrayexpress
GenomicsComparative profiling of chromatin state maps and transcription factor occupancy during human fetal and adult erythropoiesis
We report the comparative investigation of genome-wide chromatin state maps, transcription factor (TF) occupancy, and gene expression profiles from developing red cell precursors at two developmental stages. Contrasting the similarities and differences between fetal and adult erythropoiesis provides...
ORGANISM(S): Homo sapiens 
2012-10-05 | E-GEOD-36985 | biostudies-arrayexpress
UnknownMutations in TBX18 Cause Dominant Urinary Tract Malformations via Transcriptional Dysregulation of Ureter Development.
Not available
S-EPMC4862256 | biostudies-literature
UnknownGenome 10K: a proposal to obtain whole-genome sequence for 10,000 vertebrate species.
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S-EPMC2877544 | biostudies-literature
UnknownSpecimen collection is essential for modern science
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S-EPMC10664955 | biostudies-literature
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S-EPMC5643159 | biostudies-literature
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S-EPMC4231481 | biostudies-literature
UnknownThe Molecular Taxonomy of Primary Prostate Cancer.
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S-EPMC4695400 | biostudies-literature
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