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ProteomicsEnhancing KLF15 Activity in Cardiomyocytes: A Novel Approach to Prevent Pathological Reprogramming and Fibrosis via Nuclease-Deficient dCas9VPR
Transcriptional activity perturbation holds promise for selectively modulating harmful transcriptional networks, but its therapeutic potential remains largely unexplored. We employed a network-based analysis of single-cell heart transcriptomes to identify transcription factor activities linked to pa...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-03-09 | PXD072456 | Pride
ProteomicsThe transaminase-ω-amidase pathway is a redox switch in glutamine metabolism that generates α-ketoglutarate
Oxidative stress is caused by short-lived molecules and metabolic changes belong to the fastest cellular responses. Here we studied how the endothelial cell metabolome reacts to acute oxidative challenges (menadione or H2O2) to identify redox-sensitive metabolic enzymes. H2O2 selectively increased α...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD055885 | Pride
Glutamine metabolism  oxidative stress  ω-amidase  reactive oxygen species  endothelial cells  α-ketoglutarate  α-ketoglutaramate  salvage pathway  kynurenine aminotransferases  nitrilase 
UnknownProposed definition of competencies for surgical neuro-oncology training.
Not available
S-EPMC8131302 | biostudies-literature
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