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ProteomicsPrognostic Markers in Triple-Negative Breast Cancer
There are no widely-accepted prognostic markers currently available to predict outcomes in patients with triple-negative breast cancer (TNBC), and no targeted therapies with confirmed benefit. We have used MALDI mass spectrometry imaging (MSI) of tryptic peptides to compare regions of cancer and ben...
ORGANISM(S): Homo sapiens (Human) 
2019-05-06 | PXD013397 | Pride
Human Breast cancer Triple-negative Maldi imaging 
MetabolomicsMetabolic differences in ripening of Solanum lycopersicum 'Ailsa Craig' and three monogenic mutants
Application of mass spectrometry enables the detection of metabolic differences between groups of related organisms. Differences in the metabolic fingerprints of wild-type Solanum lycopersicum and three monogenic mutants, ripening inhibitor (rin), non-ripening (nor) and Colourless non-ripening (Cnr)...
2014-02-07 | MTBLS36 | MetaboLights
MetabolomicsMetabolic differences in ripening of Solanum lycopersicum 'Ailsa Craig' and three monogenic mutants (alternative assay to MTBLS36)
The purpose of this study was to highlight metabolic differences between different cultivars of tomato through development and ripening. Application of mass spectrometry enables the detection of metabolic differences between groups of related organisms. Differences in the metabolic fingerprints of w...
2017-10-18 | MTBLS73 | MetaboLights
TranscriptomicsTranscriptomic comparison of fructose and lipid grown cultures of Ralstonia eutropha H16
Whole genome gene expression analysis was examined with Ralstonia eutropha strain H16 cultures grown in PHB production medium (recipe per Peoples and Sinskey, 1989) containing fructose or trioleate as the main carbon source. The goal of this analysis was to determine the identity of the triacylglyc...
ORGANISM(S): Cupriavidus necator 
2010-08-26 | E-GEOD-21145 | biostudies-arrayexpress
TranscriptomicsActivation of IFN/STAT1 signaling is a hallmark of response to chemotherapy in patient-derived xenografts of triple-negative breast cancer
By using patient-derived xenografts (PDXs) as living surrogate of the clinical practice, we identify here induction of genes related to the IFN pathway as an early and specific predictor of tumor response to treatment. Gene expression profile of tumor cells after laser-capture microdissection of res...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-58990 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human breast cancer cell lines to investigate p53 status in breast cancer
Breast cancer subtypes identified in genomic studies have different underlying genetic defects. Mutations in the tumor suppressor p53 occur more frequently in estrogen receptor (ER) negative, basal-like and HER2-amplified tumors than in luminal, ER positive tumors. Thus, because p53 mutation statu...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3178 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptional response of Clostridium difficile carrying the M-OM-^UCD38-2 prophage
We used RNA-seq to conduct a genome-wide transcriptomic analysis of the C. difficile strain R20291 carrying the newly introduced M-OM-^UCD38-2 prophage. A total of 39 bacterial genes were differentially expressed in the R20291 lysogen, 26 of them being downregulated. Several of the regulated genes e...
ORGANISM(S): Peptoclostridium difficile 
2014-12-22 | E-GEOD-56818 | biostudies-arrayexpress
UnknownMutations in ATP1A1 Cause Dominant Charcot-Marie-Tooth Type 2.
Not available
S-EPMC5985288 | biostudies-literature
MetabolomicsEffects of a Compound from the Group of Substituted Thiadiazines with Hypothermia Inducing Properties on Brain Metabolism in Rats, a Study In Vivo and In Vitro
The aim of the present study was to examine how administration of a compound of 1,3,4-thiadiazine class 2-morpholino-5-phenyl-6H-1,3,4-thiadiazine hydrobromide (L-17) with hypothermia inducing properties affects the brain metabolism. The mechanism by which L-17 induces hypothermia is unknown; it may...
2018-07-27 | MTBLS482 | MetaboLights
UnknownHybrid glasses from strong and fragile metal-organic framework liquids.
Not available
S-EPMC4560802 | biostudies-literature
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