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TranscriptomicsMolecular Rejuvenation of Gene Expression Pattern of Photoaged and Intrinsically Aged Human Skin by Broadband Light Treatment
Studies in model organisms suggest that aged cells can be functionally rejuvenated, but whether this concept applies to human skin is unclear. Here we apply deep sequencing of RNA 3' ends ("3-seq") to discover the gene expression program associated with human photoaging and intrinsic skin ...
ORGANISM(S): Homo sapiens 
2012-07-30 | E-GEOD-39170 | biostudies-arrayexpress
TranscriptomicsDisruption of the phosphate transporter Pit1 in hepatocytes improves glucose metabolism and insulin signalling by modulating the USP7/IRS1 interaction.
The liver plays a central role in whole-body lipid and glucose homeostasis. Increasing dietary fat intake results in increased hepatic fat deposition, which is associated with a risk for development of insulin resistance and type 2 diabetes. In this study, we demonstrate a role for the phosphate ino...
ORGANISM(S): Mus musculus 
2016-08-25 | E-MTAB-4989 | biostudies-arrayexpress
TranscriptomicsA module-based translational strategy shows a central role for S100A4 in allergy
The involvement of thousands of genes complicates the identification of clinically relevant candidate genes in common diseases. We hypothesized that genes co-regulated with a key gene in allergy, IL13, would form a module that could help to discover novel candidate genes. We identified a Th2 cell mo...
ORGANISM(S): Homo sapiens 
2014-02-05 | E-GEOD-46333 | biostudies-arrayexpress
MetabolomicsSystematic analyses of lipid mobilization by human lipid transfer proteins

Lipid transfer proteins (LTPs) maintain the specialised lipid compositions of biological membranes, and many are associated with disease. In eukaryotes, they support organellar functions by transporting lipids between compartmentalised metabolic pathways. However, for the majority of the hundreds...

2025-11-14 | MTBLS9567 | MetaboLights
UnknownEffects of Two Types of Melatonin-Loaded Nanocapsules with Distinct Supramolecular Structures: Polymeric (NC) and Lipid-Core Nanocapsules (LNC) on Bovine Embryo Culture Model.
Not available
S-EPMC4910990 | biostudies-literature
UnknownNon-CG DNA methylation is a biomarker for assessing endodermal differentiation capacity in pluripotent stem cells.
Not available
S-EPMC4740175 | biostudies-literature
TranscriptomicsA daily temporal program for rhythmic expression of protein-coding and non-coding genes in response to light and dark in Synechocystis sp. PCC 6803
We investigated Synechocystis high-density microarray data of three high-resolution time-series experiments with alternating light/dark rhythm, transition to continuous light, and transition to continuous darkness. Using M-bM-^@M-^Xleast oscillating setM-bM-^@M-^Y normalization and a clustering appr...
ORGANISM(S): Synechocystis sp. PCC 6803 
2013-05-30 | E-GEOD-47482 | biostudies-arrayexpress
UnknownRisk factors for depression and anxiety in painful and painless diabetic polyneuropathy: A multicentre observational cross-sectional study.
Not available
S-EPMC9293147 | biostudies-literature
TranscriptomicsHumanMethylation450 (450k) data for 79 rheumatoid arthritis disease discordant monozygotic twin pairs
This project contains genome-wide DNA methylation data generated using the HumanMethylation450 BeadChip (Illumina), for 79 rheumatoid arthritis (RA) discordant monozygotic twin pairs. By investigating disease discordant monozygotic twins, DNA methylation can be assessed without the confounding influ...
ORGANISM(S): Homo sapiens 
2018-07-24 | E-MTAB-6988 | biostudies-arrayexpress
GenomicsA comprehensive assessment of somatic mutation detection in cancer using whole genome sequencing
As whole genome sequencing for cancer genome analysis becomes a clinical tool, a full understanding of the variables affecting sequencing analysis output is required. Using tumor-normal sample pairs from two different types of cancer, chronic lymphocytic leukemia and medulloblastoma, we conducted a ...
EGAS00001001539 | EGA
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