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A1AT deficiency is an autosomal not recessive disorder caused by mutations in the SERPINA1 gene. Individuals with the Z variant retain polymerised protein in the endoplasmic reticulum of hepatocytes, predisposing them to liver disease. This study primarily aimed to uncover the molecular mechanisms t...
ORGANISM(S): Homo sapiens 
We investigated the effects of the variation in intracellular adenylic nucleotides pools due to the absence of the adenylate kinase Adk1p on the global yeast transcriptome. In this work, global transcription analyses were combined to measurements of intracellular nucleotides pools by HPLC. Keywords:...
ORGANISM(S): Saccharomyces cerevisiae 
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