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This was an accompanying experiment. Previously, the expression of genes hsp70A and hsp70B had been established as being tetrapyrrole-dependent (Kropat et al., 1997, 2000). Since both are well-known heat-shock proteins, we performed a one-step heat shock treatment by shifting the temperatures from 2...
ORGANISM(S): Chlamydomonas reinhardtii 
Aberrant expression of histone deacetylases (HDACs) and their activity are associated with a broad range of tumor development. However, based on cell or tissue types, class IIA HDACs such as HDAC4 and HDAC5 may facilitate or inhibit cancer progression. The goal of this project is to examine the gene...
ORGANISM(S): Homo sapiens 
ER-associated degradation (ERAD) is an evolutionarily-conserved quality control mechanism where misfolded proteins are removed from the endoplasmic reticulum (ER) and degraded by the ubiquitin-proteasome system. While many ERAD-mediating proteins have been identified, it is unknown how they are spat...
ORGANISM(S): Chlamydomonas reinhardtii 
2020-05-26 | PXD009375 | Pride
To find out the identities of microtubule-associated proteins whose abundances are visibly reduced in presence of Taxol. For this experiment, microtubule-associated proteins are pulleddown after treatment with Taxol. Untreated cells are used as a control.
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD035700 | Pride
We investigated Synechocystis high-density microarray data of three high-resolution time-series experiments with alternating light/dark rhythm, transition to continuous light, and transition to continuous darkness. Using M-bM-^@M-^Xleast oscillating setM-bM-^@M-^Y normalization and a clustering appr...
ORGANISM(S): Synechocystis sp. PCC 6803 
Bam files for 124 samples (62 tumor vs blood pairs); Whole Genome Sequencing performed on Illumina HiSeq X Ten
Bam files for 16 meningioma tumor samples; ChIPseq performed on Illumina HiSeq 2000
DNA methylation patterns delineate clinically relevant subgroups of meningioma. We previously established the six meningioma methylation classes (MC) benign-1, 2, 3, intermediate-A, B and malignant. Here, we set out to identify subgroup-specific mutational patterns and pathway regulation. Whole-gen...
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