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TranscriptomicsThe role of miRNAs in neuroblastoma tumor development
Neuroblastoma (NB) is an embryonic tumor arising from immature sympathetic nervous system progenitor cells. MYCN and ALK are driver oncogenes both of which are specifically expressed during early neurogenesis. This is in line with the assumption that NB arises through disruption of normal developmen...
ORGANISM(S): Mus musculus 
2014-10-01 | E-MTAB-2618 | biostudies-arrayexpress
TranscriptomicsTargeting super-enhancer induced gene expression using novel BRD4 inhibitor OTX015 in preclinical models of MYCN-amplified neuroblastoma
Bromodomain-containing protein 4 (BRD4) functions as an epigenetic reader and binds to so-called super-enhancer regions of driving oncogenes such as MYC in cancer. We investigated the possibility to target super-enhancer regulated genes in neuroblastoma and in MYCN amplified disease in particular. W...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-MTAB-3672 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of MYCN-driven neuroblastoma tumor development in the TH-MYCN mouse model.
Neuroblastoma is an embryonic tumor arising from immature sympathetic nervous system progenitor cells. MYCN and ALK are driver oncogenes both of which are specifically expressed during early neurogenesis. This is in line with the assumption that neuroblastoma arises through disruption of normal deve...
ORGANISM(S): Mus musculus 
2016-02-28 | E-MTAB-3247 | biostudies-arrayexpress
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