Chromosomal instability (CIN) is defined by the propensity to acquire structural and/or numerical aberration in the normal cellular karyotype and is often associated with cancer. Autophagy is a catabolic process that leads to the recycling of cellular components that may positively or negatively imp...
Age-related obesity is a growing public health concern since it contributes to a multitude of metabolic disorders, yet its mechanisms remain poorly defined. Herein, we report that S-nitrosoglutathione reductase (GSNOR), a pivotal enzyme for de-nitrosation, significantly increased in adipose tissues...
Proper control of inflammatory responses is essential for embryonic development, but the underlying mechanism is poorly understood. Here, we show that under physiological conditions, inactivation of ISG15, an inflammation amplifier, is associated with the interaction of Beclin 1 (Becn1), via its ECD...
DNA mismatch repair (MMR) is essential for maintaining genome integrity, yet its regulation by non-protein biomolecules remains poorly understood. Here, we uncover nuclear phosphatidylinositol 3-phosphate (PI3P) as a previously unrecognized lipid mediator of MMR. PI3P, canonically produced by the Be...
A comprehensive gene expression analysis was performed on a co-culture of breast cancer cells and mesenchymal stromal cells, the latter of which either expressed beclin-1 or was depleted of beclin-1 by siRNA.
Age-related obesity is a growing public health concern linked to various metabolic disorders, yet its underlying mechanisms remain incompletely understood. Here we report that S-nitrosoglutathione reductase (GSNOR), a pivotal denitrosation enzyme, increases in adipose tissue of both male mice and hu...
