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ProteomicsAge-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy
To gain understanding on the mechanisms that drive immunosenescence in humans, we examined CD4+ T cells obtained from younger (20-39 years-old) and older (70+ years-old) healthy participants of the Baltimore Longitudinal Study on Aging (BLSA). We found that mitochondrial proteins involved in the el...
ORGANISM(S): Homo sapiens (Human) 
2019-11-27 | PXD016039 | Pride
Autophagy Proteomics Mitochondria Cd4+ t cells Aging 
TranscriptomicsAge-associated Changes in Basal NF-κB Function in Human CD4+ T Lymphocytes via Dysregulation of PI3 Kinase (dataset 1)
Immune impairment and high circulating level of pro-inflammatory cytokines are landmarks of human aging. However, the molecular basis of immune dysregulation and the source of inflammatory markers remain unclear. Here we demonstrate that in the absence of overt cell stimulation, gene expression medi...
ORGANISM(S): Homo sapiens 
2015-01-08 | E-GEOD-62331 | biostudies-arrayexpress
TranscriptomicsAge-associated Changes in Basal NF-κB Function in Human CD4+ T Lymphocytes via Dysregulation of PI3 Kinase (dataset 2)
Immune impairment and high circulating level of pro-inflammatory cytokines are landmarks of human aging. However, the molecular basis of immune dysregulation and the source of inflammatory markers remain unclear. Here we demonstrate that in the absence of overt cell stimulation, gene expression medi...
ORGANISM(S): Homo sapiens 
2015-01-08 | E-GEOD-62332 | biostudies-arrayexpress
TranscriptomicsAge-associated Changes in Basal NF-κB Function in Human CD4+ T Lymphocytes via Dysregulation of PI3 Kinase (dataset 5)
Immune impairment and high circulating level of pro-inflammatory cytokines are landmarks of human aging. However, the molecular basis of immune dysregulation and the source of inflammatory markers remain unclear. Here we demonstrate that in the absence of overt cell stimulation, gene expression medi...
ORGANISM(S): Homo sapiens 
2015-01-08 | E-GEOD-62375 | biostudies-arrayexpress
TranscriptomicsAge-associated Changes in Basal NF-κB Function in Human CD4+ T Lymphocytes via Dysregulation of PI3 Kinase (dataset 3)
Immune impairment and high circulating level of pro-inflammatory cytokines are landmarks of human aging. However, the molecular basis of immune dysregulation and the source of inflammatory markers remain unclear. Here we demonstrate that in the absence of overt cell stimulation, gene expression medi...
ORGANISM(S): Homo sapiens 
2015-01-08 | E-GEOD-62373 | biostudies-arrayexpress
TranscriptomicsAge-associated Changes in Basal NF-κB Function in Human CD4+ T Lymphocytes via Dysregulation of PI3 Kinase (dataset 4)
Immune impairment and high circulating level of pro-inflammatory cytokines are landmarks of human aging. However, the molecular basis of immune dysregulation and the source of inflammatory markers remain unclear. Here we demonstrate that in the absence of overt cell stimulation, gene expression medi...
ORGANISM(S): Homo sapiens 
2015-01-08 | E-GEOD-62374 | biostudies-arrayexpress
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