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TranscriptomicsIN VITRO ASSESSMENT OF ACUTE EXPOSURE OF THS2.2 AEROSOL ON ORGANOTYPIC ACUTE HUMAN BRONCHIAL TISSUE CULTURES
In vitro toxicology approaches have evolved, from a focus on the molecular changes within a cell to understanding of toxicity-related mechanisms that simulate the in vivo environment. The recent development of three dimensional (3-D) organotypic nasal epithelial culture models offer a physiologicall...
ORGANISM(S): Homo sapiens 
2016-12-01 | E-MTAB-5179 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of blood exposure response gene signature across clinical studies on The Tobacco Heating System 2.2 (THS 2.2) dataset 1
As part of current harm reduction strategies, candidate modified risk tobacco products (MRTP)s are developed to offer adult smokers who want to continue using tobacco products as an alternative to cigarettes while potentially reducing individual risk and population harm compared to smoking cigarette...
ORGANISM(S): Homo sapiens 
2019-06-30 | E-MTAB-6558 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of blood exposure response gene signature across clinical studies on The Tobacco Heating System 2.2 (THS 2.2) dataset 2
As part of current harm reduction strategies, candidate modified risk tobacco products (MRTP)s are developed to offer adult smokers who want to continue using tobacco products as an alternative to cigarettes while potentially reducing individual risk and population harm compared to smoking cigarette...
ORGANISM(S): Homo sapiens 
2019-06-30 | E-MTAB-6559 | biostudies-arrayexpress
TranscriptomicsAIR100 SysBio Approach
Organotypic culture of human primary bronchial epithelial cells is a useful in vitro system to study normal biological processes and lung disease mechanisms, to develop new therapies, and to assess the biological perturbations induced by environmental pollutants. Herein, we further develop this in v...
ORGANISM(S): Homo sapiens 
2012-04-01 | E-MTAB-877 | biostudies-arrayexpress
TranscriptomicsIN VITRO SYSTEMS TOXICOLOGY ASSESSMENT OF A PROTOTYPIC MODIFIED RISK TOBACCO PRODUCT SHOWS REDUCED TOXICITY COMPARED TO A CONVENTIONAL CIGARETTE
The toxicity and potential associated molecular mechanism of a reference cigarette, 3R4F and THS2.2 a candidate modified risk tobacco products ((p)MRTP) were investigated with human bronchial epithelial cells using high-throughput screening and whole transcriptomics analysis.
ORGANISM(S): Homo sapiens 
2016-01-05 | E-MTAB-3738 | biostudies-arrayexpress
TranscriptomicsToxicity of the main electronic cigarette components, propylene glycol, glycerin and nicotine in Sprague Dawley rats in a 90-day OECD inhalation study complemented with molecular endpoints (RNE)
While the toxicity of the main constituents of electronic cigarette (ECIG) liquids, nicotine, propylene glycol (PG), and vegetable glycerin (VG), has been assessed individually in separate studies, limited data on the inhalation toxicity of them is available when in mixtures. In this 90-day subchron...
ORGANISM(S): Rattus norvegicus 
2017-11-03 | E-MTAB-5910 | biostudies-arrayexpress
TranscriptomicsEvaluation of the Tobacco Heating System 2.2 (THS2.2). Part 5: microRNA expression from a 90-day rat inhalation study indicates that exposure to THS 2.2 aerosol causes reduced effects on lung tissue compared with cigarette smoke
Modified-risk tobacco products (MRTP) are designed to reduce the individual risk of tobacco-related disease as well as population harm compared to smoking cigarettes. Experimental proof of their benefit needs to be provided at multiple levels in research fields. Here, we examined microRNA (miRNA) le...
ORGANISM(S): Rattus norvegicus 
2016-11-30 | E-MTAB-5296 | biostudies-arrayexpress
TranscriptomicsA systems toxicology approach for comparative assessment: Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic bronchial epithelial cultures (miRNA data)
This study reports a comparative assessment of the biological impact of a heated tobacco aerosol from the tobacco heating system (THS) 2.2 and smoke from a combustible 3R4F cigarette. Human organotypic bronchial epithelial cultures were exposed to an aerosol from THS2.2 (a candidate modified-risk to...
ORGANISM(S): Homo sapiens 
2016-12-15 | E-MTAB-5318 | biostudies-arrayexpress
TranscriptomicsIdentification of gene expression signature for cigarette smoke exposure response--from man to mouse.
As part of current harm reduction strategies, candidate modified risk tobacco products (MRTP) are developed to offer adult smokers who want to continue using tobacco product an alternative to cigarettes while potentially reducing individual risk and population harm compared to smoking cigarettes. On...
ORGANISM(S): Homo sapiens 
2017-08-05 | E-MTAB-5332 | biostudies-arrayexpress
TranscriptomicsToxicity of Toxicity of the main electronic cigarette components, propylene glycol, glycerin and nicotine in Sprague Dawley rats in a 90-day OECD inhalation study complemented with molecular endpoints (Liver)
The main constituents of electronic cigarette liquids are nicotine, propylene glycol (PG), and vegetable glycerin (VG), together with distilled water and flavors. To assess the toxicity of PG/VG mixtures with and without nicotine as basic components of liquids used in e-cigarettes, a 90-day rat inha...
ORGANISM(S): Rattus norvegicus 
2017-11-03 | E-MTAB-5544 | biostudies-arrayexpress
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