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TranscriptomicsDetermining the impact of alternative splicing events on transcriptome dynamics
Background The complete sequencing of the human genome and its subsequent analysis revealed a predominant role for alternative splicing in the generation of proteome diversity. Splice switching oligonucleotides (SSOs) are a powerful and specific tool to experimentally control alternative splicing of...
ORGANISM(S): Homo sapiens 
2008-10-02 | E-GEOD-9851 | biostudies-arrayexpress
Transcriptomicsp53 independent TAF6delta target genes.
To elucidate the impact of TAF6d on cell death and gene expression, here we have employed modified antisense oligonucleotides to enforce expression of endogenous TAF6d. The induction of endogenous TAF6d triggered apoptosis in tumor cell lines, including cells devoid of p53. Microarray experiments re...
ORGANISM(S): Homo sapiens 
2008-06-26 | E-GEOD-10795 | biostudies-arrayexpress
TranscriptomicsTAF6 orchestrates transcription programs and apoptosis in the absence of p53
The decision of metazoan cells to live or undergo programmed cell death hinges on the balance between the levels of pro- versus anti-apoptotic gene products. The general RNA polymerase II (Pol II) transcription factor, TFIID, plays a central role in the regulation of gene expression through its core...
ORGANISM(S): Homo sapiens 
2010-11-27 | E-GEOD-8752 | biostudies-arrayexpress
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