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TranscriptomicsExpression data from human pluripotent stem cells and differentiated cells treated with pluripotent-specific inhibitors
The use of human pluripotent stem cells (hPSCs) in cell therapy is hindered by the tumorigenic risk from residual undifferentiated cells. Here we performed a high-throughput screen of over 52,000 small molecules, and identified 15 highly selective cytotoxic inhibitors of hPSCs (PluriSIns). Cellular ...
ORGANISM(S): Homo sapiens 
2013-01-22 | E-GEOD-37040 | biostudies-arrayexpress
TranscriptomicsExpression data from diploid human pluripotent stem cells
Human pluripotent stem cells (hPSCs) tend to acquire chromosomal aberrations in culture, which may increase their tumorigenicity. However, the cellular mechanism(s) underlying these aberrations are largely unknown. Here we show that the DNA replication in aneuploid hPSCs is perturbed, resulting in h...
ORGANISM(S): Homo sapiens 
2015-11-12 | E-GEOD-64647 | biostudies-arrayexpress
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