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TranscriptomicsIdentification of Resistance Genes to BRAF Inhibitor in Melanoma by piggyBac Transposon Activation Mutagenesis Screen
Genotype directed anti-cancer therapies such BRAF inhibitor in BRAF mutant melanoma can show remarkable clinical efficacy but resistance limits their benefit. We show that a transposon activation screen efficiently identifies resistance genes to BRAF and captures a number of previously uncharacteriz...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-73470 | biostudies-arrayexpress
TranscriptomicsHER2 expression identifies dynamic functional states within circulating breast cancer cells
Circulating tumour cells in women with advanced oestrogen-receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer acquire a HER2-positive subpopulation after multiple courses of therapy. In contrast to HER2-amplified primary breast cancer, which is highly sensit...
ORGANISM(S): Homo sapiens 
2016-08-25 | E-GEOD-75367 | biostudies-arrayexpress
UnknownTang Mitosis/Apoptosis ver. II
Not available
2016-07-12 | LDS-1004 | LINCS
TranscriptomicsThe apoptotic network and expression of BH3-containing proteins predict phenotypic response to BET bromodomain inhibitors
Small molecule inhibitors of the bromodomain and extraterminal (BET) family of proteins are in clinical trials for a variety of cancers, but patient selection strategies are limited. This is due in part to the heterogeneity of response following BET inhibition (BETi), which includes differentiation...
ORGANISM(S): Homo sapiens 
2016-01-07 | E-GEOD-69383 | biostudies-arrayexpress
TranscriptomicsTargeting transcriptional dependencies in cancer using a covalent CDK7 inhibitor (expression)
Cyclin-dependent kinase 7 (CDK7) plays a critical role in the general regulation of RNA polymerase II-mediated transcription. However, the absence of selective CDK7 inhibitors has hindered the ability to investigate the consequences of acute and prolonged inhibition of CDK7 under normal and patholo...
ORGANISM(S): Homo sapiens 
2014-06-22 | E-GEOD-50624 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of ex vivo culture of circulating breast tumor cells
Analyses of circulating tumor cells (CTC) cultured from blood of patients with cancer may allow individualized testing for susceptibility to therapeutic regimens. We established ex vivo cultures of CTCs from six patients with metastatic estrogen receptor-positive breast cancer and performed RNA-Seq...
ORGANISM(S): Homo sapiens 
2014-07-11 | E-GEOD-55807 | biostudies-arrayexpress
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