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UnknownDepletion of SAM leading to loss of heterochromatin drives muscle stem cell ageing.
Not available
S-EPMC10976122 | biostudies-literature
TranscriptomicsTranscription profiling of rat fetal lung cells exposed to mechanical forces reveals expression of novel genes
Mechanical forces are essential for normal fetal lung development. However, the cellular and molecular mechanisms regulating this process remain largely unknown. In the present study, we used oligonucleotide microarray technology to investigate gene expression profile in cultured rat fetal lung typ...
ORGANISM(S): Rattus norvegicus 
2007-06-29 | E-GEOD-3541 | biostudies-arrayexpress
TranscriptomicsEngineering acetyl-CoA supply: Functional expression of a bacterial pyruvate-dehydrogenase complex in the cytosol of Saccharomyces cerevisiae
The energetic (ATP) cost of biochemical pathways critically determines the maximum yield of metabolites of vital or commercial relevance. Cytosolic acetyl-CoA is a key precursor for biosynthesis in eukaryotes and for many industrially relevant product pathways that have been introduced into Saccharo...
ORGANISM(S): Saccharomyces cerevisiae 
2014-11-04 | E-GEOD-59814 | biostudies-arrayexpress
TranscriptomicsReplacement of the Saccharomyces cerevisiae acetyl-CoA synthetases by alternative pathways for cytosolic acetyl-CoA synthesis
Cytosolic acetyl-coenzyme A is a precursor for many biotechnologically relevant compounds produced by Saccharomyces cerevisiae. In this yeast, cytosolic acetyl-CoA synthesis and growth strictly depend on expression of either the Acs1 or Acs2 isoenzyme of acetyl-CoA synthetase (ACS). Since hydrolysis...
ORGANISM(S): Saccharomyces cerevisiae 
2013-11-21 | E-GEOD-47983 | biostudies-arrayexpress
TranscriptomicsBASE-A space experiment with Rhodospirillum rubrum S1H
R. rubrum S1H inoculated on solid minimal media was sent to the ISS in September 2006 (BASE-A experiment). After 10 days flight, R. rubrum cultures returned back to Earth. These cultures were then subjected to both transcriptomic and proteomic analysis and compared with the corresponding ground cont...
ORGANISM(S): Rhodospirillum rubrum 
2010-05-16 | E-GEOD-14241 | biostudies-arrayexpress
GenomicsWidespread Cap-Unmethylated mRNAs Revealed by Metabolic Stress
Widespread Cap-Unmethylated mRNAs Revealed by Metabolic Stress
PRJNA1377480 | ENA
ProteomicsGuanine-containing ssDNA and RNA induce dimeric and tetrameric SAMHD1 in cryo-EM and binding studies
The dNTPase activity of tetrameric SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1) plays a critical role in cellular dNTP regulation. SAMHD1 also associates with stalled DNA replication forks, DNA repair foci, ssRNA, and telomeres. The above functions require...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2023-11-13 | PXD043587 | Pride
Aicardi-goutieres syndrome Dna repair Rnase Sammhd1 Hiv 
TranscriptomicsEffects of pregnancy and progesterone supplementation on endometrial gene expression in cattle
An increase in circulating progesterone (P4) concentrations is associated with increased pregnancy success in beef and dairy cattle. Our objective was to ascertain differential effects of elevated P4 concentrations following conception on endometrial gene expression in beef heifers on Days 5, 7, 13 ...
ORGANISM(S): Bos taurus 
2011-10-17 | E-GEOD-33030 | biostudies-arrayexpress
TranscriptomicsThe carbonic anhydrase inhibitor ethoxzolamide inhibits the Mycobacterium tuberculosis PhoPR regulon and Esx-1 secretion and attenuates virulence
The purpose of this study was to examine how ethoxzolamide modulates gene M. tuberculosis gene expression at acidic pH. We observed that ethoxzolamide downregulates genes of the PhoPR regulon. Mtb strain CDC1551 was grown at 37C in T-25 vented, standing tissue culture flasks in 8 ml of buffered 7H9 ...
ORGANISM(S): Mycobacterium tuberculosis 
2015-05-20 | E-GEOD-63917 | biostudies-arrayexpress
TranscriptomicsMESSAGE 2 space experiment with Rhodospirillum rubrum S1H
R. rubrum S1H inoculated on solid agar rich media was sent to the ISS in October 2003 (MESSAGE-part 2 experiment). After 10 days flight, R. rubrum cultures returned back to Earth. These cultures were then subjected to both transcriptomic and proteomic analysis and compared with the corresponding gr...
ORGANISM(S): Rhodospirillum rubrum 
2010-05-16 | E-GEOD-14239 | biostudies-arrayexpress
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