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TranscriptomicsA systematic approach to the metastatically relevant microRNA landscape
Identification of differentially expressed microRNAs in Colorectal Cancer Distant metastasis is the major determinant of patient outcome in colorectal cancer and microRNAs have emerged as an increasingly important class of molecules which can regulate several steps of the metastatic cascade. By syst...
ORGANISM(S): Homo sapiens 
2014-01-16 | E-GEOD-54088 | biostudies-arrayexpress
TranscriptomicsArray-CGH screening of medulloblastoma
DNA copy-number profiling of 80 primary medulloblastomas of different histologies Keywords: Genetic modification Comparison of tumor DNA (medulloblastoma) versus control DNA (pool of lymphocyte DNA from 10 healthy donors). Whole-genome screening for DNA copy-number aberrations using array-based comp...
ORGANISM(S): Homo sapiens 
2007-08-01 | E-GEOD-8634 | biostudies-arrayexpress
TranscriptomicsDecoding differentially regulated epithelial and stromal pathways in colorectal cancer
Analysis of differentially expressed genes from dissected whole tissue and laser capture microdissected colorectal cancer tissue samples The analysis, in colorectal cancer tissues, of compartmental and whole tissue expression profiles as well as the significantly active pathways that were differenti...
ORGANISM(S): Homo sapiens 
2011-08-09 | E-GEOD-31279 | biostudies-arrayexpress
TranscriptomicsExpression profiling of human primary breast cancer tissue before treatment with gemcitabine, epirubicine and docetaxel
Gene expression profiles of human breast cancer tissues from 100 different patients treated with primary systemic chemotherapy (Gemcitabine, Epirubicin and Docetaxel) Keywords: expression profiling Human breast cancer tissues from 100 patients have been used to perform expression profiling analysis...
ORGANISM(S): Homo sapiens 
2006-01-21 | E-GEOD-4056 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of neuroblastoma tumors with and without MYCN amplification
Purpose: Clinical courses of neuroblastomas (NBs) range from rapid progression with fatal outcome despite intensive multimodality therapies to spontaneous regression. Amplified MYCN oncogene defines a subgroup with poor outcome. However, a substantial number of MYCN single-copy NBs exhibits an aggre...
ORGANISM(S): Homo sapiens 
2007-06-01 | E-CVDE-2 | biostudies-arrayexpress
TranscriptomicsS080_BrCaRes_Schneeweiss et al.
In patients with primary breast cancer, neoadjuvant chemotherapy with doxorubicin plus pemetrexed followed by docetaxel (AP-D) is associated with a pathologic complete response (pCR) rate of 16.5%, and doxorubicin plus cyclophosphamide followed by docetaxel (AC-D) is associated with a pCR rate of 20...
ORGANISM(S): Homo sapiens 
2014-02-01 | E-TABM-1186 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human neuroblastoma cells with and without MYCN oncogene induction and doxorubicin treatment
Purpose: Clinical courses of neuroblastomas (NBs) range from rapid progression with fatal outcome despite intensive multimodality therapies to spontaneous regression. Amplified MYCN oncogene defines a subgroup with poor outcome. However, a substantial number of MYCN single-copy NBs exhibits an aggre...
ORGANISM(S): Homo sapiens 
2007-06-01 | E-CVDE-3 | biostudies-arrayexpress
TranscriptomicsDNA methylation data from primary neuroblastoma tumors
Genome wide DNA methylation profiling of primary neuroblastomas. The Illumina 450k methylation array was used to obtain DNA methylation profiles across approximately 485,000 CpGs in 105 neuroblastomas. Tumors were derived from 40 low-risk, 9 intermediate-risk and 56 high-risk patients. Bisulphite c...
ORGANISM(S): Homo sapiens 
2016-09-08 | E-GEOD-73515 | biostudies-arrayexpress
TranscriptomicsRNA expression data from primary neuroblastoma tumors
RNA expression profiles of 105 primary neuroblastomas derived from customized 4 x 44k oligonucleotide microarrays (Agilent Technologies). These profiles are part of an integrative study combining genomewide epigenetic profiles with transcriptome data of the same neuroblastoma cohort. Tumors were der...
ORGANISM(S): Homo sapiens 
2016-09-08 | E-GEOD-73517 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human testis, primary myeloma cell and normal tissue samples to identify novel cancer-testis genes
Cancer-testis (CT) antigens are attractive targets for immunotherapeutic strategies since they are aberrantly expressed in malignant cells and not, or in limited number, in somatic tissues, except germ cells. To identify novel CT genes in multiple myeloma, we used Affymetrix HG-U133 gene expression ...
ORGANISM(S): Homo sapiens 
2009-01-20 | E-MTAB-81 | biostudies-arrayexpress
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