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TranscriptomicsDifferential repression of TLR responses by PPARg and LXRs
Transrepression mediated by PPARg and LXRs agonists (GW7845 and GW3965) in primary macrophages stimulated with LPS or poly I:C. Thioglycollate-elicited macrophages were isolated from mice by peritoneal lavage 3 days following peritoneal injection of 2.5 ml 3% thioglycollate (DIFCO). Cells were plate...
ORGANISM(S): Mus musculus 
2006-12-15 | GSE6346 | GEO
TranscriptomicsComprehensive mouse alpha and beta cell transcriptomes
Rodent models are widely used to study diabetes. Yet, significant gaps remain in our understanding of mouse islet physiology that reduce their accuracy as a model for human islet disease. We generated comprehensive transcriptomes of mouse beta and alpha cells using a novel bitransgenic mouse model g...
ORGANISM(S): Mus musculus 
2014-09-16 | E-GEOD-54973 | biostudies-arrayexpress
GenomicsMus musculus
Differential repression of TLR responses by PPARg and LXRs
PRJNA99611 | ENA
GenomicsWnt3a-Activin A Synergy Induces eRNAPII Pause-Release and Counteracts a Yap1 Elongation Block during hESC Differentiation
The Wnt3a/?-catenin and Activin/Smad2,3 signaling pathways synergize to induce endodermal differentiation of human embryonic stem cells, however the mechanism is not well-understood. Using ChIP-seq and GRO-seq analyses, we report here that hESC enhancers, including Wnt3a/LEF-1 sites, hold enhancer R...
ORGANISM(S): Homo sapiens 
2015-05-04 | E-GEOD-64758 | biostudies-arrayexpress
GenomicsGenome-Wide Maps of WT and DBDmut Estrogen Receptor in Human Breast Cancer Cells
We wanted to explore the relative contributions of DNA binding and tethering regulation modes by the estrogen receptor in human breast cancer cells We defined the genome-wide localization of WT and DBDmut estrogen receptors in human breast cancer cells
ORGANISM(S): Homo sapiens 
2010-06-30 | E-GEOD-22609 | biostudies-arrayexpress
GenomicsPHF8 mediates histone demethylation events in cell cycle progression [ChIP-Seq]
While reversible histone modifications are linked to an ever-expanding range of biological functions, the demethylases for histone H4 lysine 20 and their potential regulatory roles remain unknown. Here, we report that the PHD and Jumonji C (JmjC) domain-containing protein, PHF8, while utilizing mul...
ORGANISM(S): Homo sapiens 
2010-09-01 | E-GEOD-22478 | biostudies-arrayexpress
no omics definedChromatin immunoprecipitation of human breast cancer cell line MCF-7 treated with 17beta-estradiol
ChIP-DSL experiments using ER alpha antibody on v1 20k promoter array
ORGANISM(S): Homo sapiens 
2007-03-31 | E-MEXP-984 | biostudies-arrayexpress
GenomicsModeling Fanconi Anemia pathogenesis and therapeutics using integration-free patient iPSCs
To elucidate the transcriptional and epigenetic alterations underlying the neurogenic defects of FA-NSCs, we conducted gene expression microarray analysis and global DNA methylation profiling. The gene expression pattern of gene-corrected NSCs (C-FA-NSCs) resembled that of control-NSCs but clustered...
ORGANISM(S): Homo sapiens 
2014-05-15 | E-GEOD-57685 | biostudies-arrayexpress
TranscriptomicsAnalysis of global gene expression profiles of A549 cells treated with XRN2 siRNA under basal conditions
Untransfected (no siRNA), control siRNA or XRN2 siRNA treated A549 cells were analyzed for gene expression differences under basal conditions 3 Biological Replicates per condition
ORGANISM(S): Homo sapiens 
2015-03-30 | E-GEOD-66662 | biostudies-arrayexpress
TranscriptomicsAnalysis of global gene expression profiles of A549 cells treated with SETX siRNA under basal conditions
Untransfected (no siRNA), control siRNA or SETX siRNA treated A549 cells were analyzed for gene expression differences under basal conditions 3 Biological Replicates per condition
ORGANISM(S): Homo sapiens 
2015-03-30 | E-GEOD-52933 | biostudies-arrayexpress
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