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TranscriptomicsTranscriptomes of Frankia sp. strain CcI3 in growth transitions
Background: Frankia sp. strains are actinobacteria that form N2-fixing root nodules on angiosperms. Several reference genome sequences are available enabling transcriptome studies in Frankia sp. Genomes from Frankia sp. strains differ markedly in size, a consequence proposed to be associated with a...
ORGANISM(S): Frankia sp. CcI3 
2011-07-15 | E-GEOD-30680 | biostudies-arrayexpress
TranscriptomicsIsocitrate dehydrogenase 1 mutations prime the all-trans-retinoic acid myeloid differentiation pathway in acute myeloid leukemia HL-60 cells
Human acute myeloid leukemia HL60 cells were transduced with IDH1-WT or IDH1-R132H, and corresponding sub-clones were generated by FACS. In a first series of experiments, cells expressing wt and mutant IDH1were treated with either 1µM all-trans retinoic acid (ATRA) or with vehicle (DMSO) for 24 hrs...
ORGANISM(S): Homo sapiens 
2017-03-01 | E-MTAB-4327 | biostudies-arrayexpress
TranscriptomicsThe Path to Triacylglyceride Obesity in the sta6 Strain of Chlamydomonas reinhardtii
When the sta6 (starch-null) strain of the green microalga Chlamydomonas reinhardtii is nitrogen-starved in acetate and then "boosted" after two days with additional acetate, the cells become "obese" after eight days, with triacylglyceride-filled lipid bodies filling their cytopla...
ORGANISM(S): Chlamydomonas reinhardtii 
2014-03-09 | E-GEOD-55253 | biostudies-arrayexpress
TranscriptomicsComparison of 2 aspen genotypes having similar carbon assimilation rates but different allocation patterns under elevated CO2
• Reference to published study making use of this data: • Cseke LJ, Tsai C-J, Rogers A, Nelsen MP, White HL, Karnosky DF, Podila GK. (2009) Transcriptomic comparison in the leaves of two aspen genotypes having similar carbon assimilation rates but different allocation patterns under elevated CO2. N...
ORGANISM(S): Populus tremuloides 
2009-03-31 | E-GEOD-14881 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of C. elegans exposed to quercetin and tannic acid
Recent research has highlighted that the polyphenols Quercetin (Q) and Tannic acid (TA) are capable of extending the lifespan of C. elegans. To gain a deep understanding of the underlying molecular genetics, we analyzed the global transcriptional patterns of nematodes exposed to Quercetin or Tannic ...
ORGANISM(S): Caenorhabditis elegans 
2012-02-03 | E-GEOD-35354 | biostudies-arrayexpress
TranscriptomicsThe Populus transciptome in elevated CO2 reveals increased anthocyanin biosynthesis during delayed autumnal senescence
Over recent decades the progression of natural autumnal senescence has been increasingly delayed across wide areas of the Northern Hemisphere and is thought to be caused by rising temperature. Recently this delay has been shown to be partly attributable to rising atmospheric carbon dioxide concentr...
ORGANISM(S): Populus x canadensis 
2010-01-31 | E-GEOD-15874 | biostudies-arrayexpress
TranscriptomicsIdentification of biomarkers that distinguish chemical contaminants using a gradient feature selection method
There are many toxic chemicals to contaminate the world and cause harm to human and other organisms. How to quickly discriminate these compounds and characterize their potential molecular mechanism and toxicity is essential. High through put transcriptomics profiles such as microarray have been prov...
ORGANISM(S): Rattus norvegicus 
2010-01-05 | E-GEOD-19662 | biostudies-arrayexpress
TranscriptomicsComparative Transcriptional Analysis of Canine and Human Diffuse Large B cell Lymphoma (DLBCL). Molecular Signatures of NF-?B Pathway Activation and Sub-Classification of Canine DLBCL.
In this study, we present the first comparison of global transcriptional changes taking place in canine lymphoma and human diffuse large B-cell lymphoma (DLBCL), with particular reference to the nuclear factor-kappaB (NF-?B) pathway. Microarray data generated from lymph nodes diagnosed with canine D...
ORGANISM(S): Canis lupus familiaris 
2013-09-26 | E-GEOD-30881 | biostudies-arrayexpress
TranscriptomicsRole of epigenetic modifiers on the bovine fibroblast innate immune response
The innate immune signaling pathway plays a crucial role in the recognition and early response to pathogens associated with disease. Genetic analysis has been unable to completely account for individual variability in the strength of the innate immune response. The aim of this study was to determine...
ORGANISM(S): Bos taurus 
2014-01-01 | E-GEOD-50405 | biostudies-arrayexpress
TranscriptomicsGenomic profiling of lymphomas in Canis lupus familiaris
Comparative oncology is a developing research discipline that is being used to assist our understanding of human neoplastic diseases. Companion canines are a preferred animal oncology model due to spontaneous tumor development and similarity to human disease at the pathophysiological level. We use ...
ORGANISM(S): Canis lupus familiaris 
2012-12-15 | E-GEOD-41917 | biostudies-arrayexpress
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