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TranscriptomicsMitofusin 2 expression in muscle decreases during aging and generates a gene signature characteristic of aged muscle
Mitochondrial fusion and fission proteins regulate mitochondrial quality control and mitochondrial metabolism. In turn, mitochondrial dysfunction is associated with aging, although its causes are still under debate. Here, we show that aging is characterized by a progressive reduction of Mitofusin 2 ...
ORGANISM(S): Mus musculus 
2016-08-08 | E-GEOD-71501 | biostudies-arrayexpress
TranscriptomicsDNA Methylation Biomarkers for Noninvasive Diagnosis of Colorectal Cancer
DNA methylation in colorectal cancer diagnosis. The Illumina GoldenGate Methylation Cancer Panel I was used to select a set of candidates markers informative of colorectal cancer diagnosis from 807 cancer-related genes. In the discovery phase, tumor tissue and paired adjacent normal mucosa from 92 c...
ORGANISM(S): Homo sapiens 
2013-05-27 | E-GEOD-43369 | biostudies-arrayexpress
TranscriptomicsProfiling of normal human colonic epithelial cells according to their PTK7 surface abundance
Human mucosa was collected from two different individuals undergoing colectomy. After treatment with EDTA, colonic crypts were isolated and further dis-aggregated using Dispase. Next, cells were stained using antibodies directed against the extracellular domain of EpCAM, PTK7, CD11, CD31, and CD45. ...
ORGANISM(S): Homo sapiens 
2016-01-12 | E-GEOD-68340 | biostudies-arrayexpress
TranscriptomicsResponse to TGFB in colon fibroblasts
We obtained gene expression signatures from TGF-beta treated fribroblasts. Upregulated genes predict poor prognosis in Colorectal Cancer. Fibroblasts extracted from human normal colon mucosa were treated with TGF-β1 for 8 hours. Gene expression profiles for treated or untreated fibroblasts were mea...
ORGANISM(S): Homo sapiens 
2015-01-28 | E-GEOD-64192 | biostudies-arrayexpress
UnknownOmbitasvir/paritaprevir/r, dasabuvir and ribavirin for cirrhotic HCV patients with thrombocytopaenia and hypoalbuminaemia.

Background & aims

Thrombocytopaenia and hypoalbuminaemia are surrogate markers for portal hypertension and hepatic synthetic dysfunction respectively. Patients infected with hepatitis C virus (HCV) with these surrogates have reduced likelihood of sustained virologic response and increased ri...
S-EPMC5049489 | biostudies-literature
UnknownEffectiveness and safety of first-generation protease inhibitors in clinical practice: Hepatitis C virus patients with advanced fibrosis.

Aim

To evaluates the effectiveness and safety of the first generation, NS3/4A protease inhibitors (PIs) in clinical practice against chronic C virus, especially in patients with advanced fibrosis.

Methods

Prospective study and non-experimental analysis of a multicentre cohort of 38 Sp...
S-EPMC4533049 | biostudies-literature
TranscriptomicsSingle-cell RNA sequencing of colorectal cancer
We profile single cells from patients with colorectum cancer using Chromium 3’ and 5’ single-cell RNA-sequencing. Patients EXT001, EXT009, and EXT012 from the KUL dataset were first analyzed by Lee et al., 2020, and the raw data are available in ArrayExpress under the accession codes E-MTAB-8410 and...
ORGANISM(S): Homo sapiens 
2022-09-16 | E-MTAB-9934 | biostudies-arrayexpress
UnknownEffectiveness and Safety of Teriflunomide in Relapsing-Remitting Multiple Sclerosis and Improvements in Quality of Life: Results from the Real-World TERICARE Study.

Introduction

Teriflunomide is a once-daily oral immunomodulator approved for relapsing forms of multiple sclerosis (MS) or relapsing-remitting multiple sclerosis (RRMS; depending on the local label), based on extensive evidence from clinical trials and a real-world setting on efficacy, toler...
S-EPMC10630277 | biostudies-literature
UnknownSeladelpar efficacy and safety at 3 months in patients with primary biliary cholangitis: ENHANCE, a phase 3, randomized, placebo-controlled study.

Background and aims

ENHANCE was a phase 3 study that evaluated efficacy and safety of seladelpar, a selective peroxisome proliferator-activated receptor-δ (PPAR) agonist, versus placebo in patients with primary biliary cholangitis with inadequate response or intolerance to ursodeoxycholic ac...
S-EPMC10344437 | biostudies-literature
UnknownENSO Drives interannual variation of forest woody growth across the tropics.
Meteorological extreme events such as El Niño events are expected to affect tropical forest net primary production (NPP) and woody growth, but there has been no large-scale empirical validation of this expectation. We collected a large high-temporal resolution dataset (for 1-13 years depending upon ...
S-EPMC6178425 | biostudies-literature
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