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ProteomicsmRNA 3’UTR lengthening by alternative polyadenylation attenuates inflammatory responses and correlates with virulence of Influenza A virus
Alternative polyadenylation (APA) leading to changes of mRNA 3’UTRs has been associated to numerous pathologies but its molecular origin and functional consequences often remain enigmatic. We show that all Influenza A virus (IAV) strains cause APA of host transcripts and mapped the effect to a dru...
ORGANISM(S): Homo sapiens (Human) 
2023-07-12 | PXD040456 | Pride
Iav Ns1 Semliki forest virus Pr8 Sfv Influenza a 
ProteomicsConcomitant targeting of viral and host methyltransferases is essential for attenuating SARS-CoV-2
LC-MS/MS based investigation of protein abundance changes, induced by DZNep treatment in A549-ACE2 cell line (0.75 uM DZNep, vehicle PBS; 6h pre-treatment, harvested 24 h.p.i. with mock/SARS-CoV/SARS-CoV-2 at MOI 3) or primary human bronchial epithelial cells (NHBEs) (1.5 uM DZNep, vehicle PBS; 6h p...
ORGANISM(S): Homo sapiens (Human) 
2022-06-28 | PXD034361 | Pride
Dznep Sars-cov-2 A549 Nhbe Tubercidin A549-ace2 
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