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UnknownEffectiveness of an intensive care telehealth programme to improve process quality (ERIC): a multicentre stepped wedge cluster randomised controlled trial.

Purpose

Supporting the provision of intensive care medicine through telehealth potentially improves process quality. This may improve patient recovery and long-term outcomes. We investigated the effectiveness of a multifaceted telemedical programme on the adherence to German quality indicato...
S-EPMC9841931 | biostudies-literature
UnknownTrans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus.
Although genome-wide association studies have provided valuable insights into the genetic basis of complex traits and diseases, translating these findings to causal genes and their downstream mechanisms remains challenging. We performed trans expression quantitative trait locus (trans-eQTL) meta-ana...
S-EPMC12491431 | biostudies-literature
UnknownLarge-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression.
Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms on the transcriptome. To investigate the genetics of gene expression, we performed cis- and trans-expression quantitative trait locus (eQTL) analyses using blood-derived expression from 31,684 individuals...
S-EPMC8432599 | biostudies-literature
UnknownDifferential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.
Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for indivi...
S-EPMC9192715 | biostudies-literature
UnknownTarget genes, variants, tissues and transcriptional pathways influencing human serum urate levels.
Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly understood mechanisms. We performed a trans-ancestry genome-wide association study of serum urate in 457,690 individuals, identifying 183 loci (147 previously unknown) that improve the prediction of gout in...
S-EPMC6858555 | biostudies-literature
UnknownA catalog of genetic loci associated with kidney function from analyses of a million individuals.
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated l...
S-EPMC6698888 | biostudies-literature
UnknownIdentification of 371 genetic variants for age at first sex and birth linked to externalising behaviour.
Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901), we identify 371 single-nucleotide polymorphisms, 11 sex-specific, with ...
S-EPMC7612120 | biostudies-literature
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