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TranscriptomicsDifferential IFNa-stimulated gene expression profiles in PLZF-inducible U937T monocyte cells
Sensitivity to Interferon (IFN) is determined by a complex coordination of genetic and environmental factors. A previous experiment using two renal cancer cell lines differing markedly in their response to IFN were analyzed for their ISG profiles in order to determine gene expression changes associa...
ORGANISM(S): Homo sapiens 
2010-05-18 | E-GEOD-16196 | biostudies-arrayexpress
TranscriptomicsGene expression arrays on lung cancer cells exposed to Notch inhibitor
Genes responses in A549 and H460 cells after GSI (RO4929097-001-003 , 2 uM) treatment. Notch signaling is an area of great interest in oncology. RO4929097 is a potent and selective inhibitor of gamma-secretase, producing inhibitory activity of Notch signaling in tumor cells. The RO4929097 IC50 in ce...
ORGANISM(S): Homo sapiens 
2012-03-01 | E-GEOD-36176 | biostudies-arrayexpress
TranscriptomicsCardiac Effects of Rosiglitazone in Male Wistar Rats
Rosiglitazone, a peroxisome proliferator-activated receptor g (PPARg) agonist of the thiazolidinedione class, is a major insulin-sensitizing drug widely used to treat type-2 diabetes. Rosiglitazone causes myocardial hypertrophy in rodents and increases the risk of cardiac events in man. To better ...
ORGANISM(S): Rattus norvegicus 
2010-07-29 | E-GEOD-22553 | biostudies-arrayexpress
TranscriptomicsTWEAK-treated time course in MDA-MB-436 cells
Tumor necrosis factor-related weak inducer of apoptosis, TWEAK, is a TNF superfamily member that mediates signaling through its receptor fibroblast growth factor inducible-14, Fn14. In tumor cell lines, TWEAK induces proliferation, survival and NF-kappaB signaling and gene expression that promote tu...
ORGANISM(S): Homo sapiens 
2013-10-04 | E-GEOD-42045 | biostudies-arrayexpress
TranscriptomicsTWEAK-treated time course in U2OS cells.
Tumor necrosis factor-related weak inducer of apoptosis, TWEAK, is a TNF superfamily member that mediates signaling through its receptor fibroblast growth factor inducible-14, Fn14. In tumor cell lines, TWEAK induces proliferation, survival and NF-kappaB signaling and gene expression that promote t...
ORGANISM(S): Homo sapiens 
2013-10-04 | E-GEOD-41828 | biostudies-arrayexpress
TranscriptomicsTWEAK-treated time course in Pan02 cells
Tumor necrosis factor-related weak inducer of apoptosis, TWEAK, is a TNF superfamily member that mediates signaling through its receptor fibroblast growth factor inducible-14, Fn14. In tumor cell lines, TWEAK induces proliferation, survival and NF-kappaB signaling and gene expression that promote tu...
ORGANISM(S): Mus musculus 
2013-10-04 | E-GEOD-42047 | biostudies-arrayexpress
TranscriptomicsTWEAK-treated time course in ACHN cells
Tumor necrosis factor-related weak inducer of apoptosis, TWEAK, is a TNF superfamily member that mediates signaling through its receptor fibroblast growth factor inducible-14, Fn14. In tumor cell lines, TWEAK induces proliferation, survival and NF-kappaB signaling and gene expression that promote tu...
ORGANISM(S): Homo sapiens 
2013-10-04 | E-GEOD-42046 | biostudies-arrayexpress
TranscriptomicsTWEAK-treated time course in CAKI cells grown as xenografts
Tumor necrosis factor-related weak inducer of apoptosis, TWEAK, is a TNF superfamily member that mediates signaling through its receptor fibroblast growth factor inducible-14, Fn14. In tumor cell lines, TWEAK induces proliferation, survival and NF-kappaB signaling and gene expression that promote tu...
ORGANISM(S): Homo sapiens 
2013-10-04 | E-GEOD-42049 | biostudies-arrayexpress
TranscriptomicsTWEAK-treated time course in ACHN cells grown as xenografts
Tumor necrosis factor-related weak inducer of apoptosis, TWEAK, is a TNF superfamily member that mediates signaling through its receptor fibroblast growth factor inducible-14, Fn14. In tumor cell lines, TWEAK induces proliferation, survival and NF-kappaB signaling and gene expression that promote tu...
ORGANISM(S): Homo sapiens 
2013-10-04 | E-GEOD-42048 | biostudies-arrayexpress
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