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TranscriptomicsIdentification of target genes of myostatin loss-of-function in the muscle of bovine fetuses
Myostatin is a highly conserved Transforming Growth Factor beta family member which negatively regulates muscle development. Double-muscled (DM) cattle have a loss-of-function mutation in their myostatin gene responsible for a hypermuscular phenotype mainly due to hyperplasia. Thus these animals rep...
ORGANISM(S): Bos taurus 
2010-07-01 | E-GEOD-5456 | biostudies-arrayexpress
TranscriptomicsIdentification of novel markers of beef sensory quality and muscle growth potential
The transcriptome of bovine Longissimus thoracis muscles from 15- and 19-month-old Charolais young bulls were analyzed in order to identify genes whose expression level was associated to beef quality scores, in particular to tenderness, juiciness and flavor, and to muscle growth potential. The expre...
ORGANISM(S): Bos taurus 
2007-08-17 | E-GEOD-5561 | biostudies-arrayexpress
TranscriptomicsEffect of High Fat Diet on gene expression of liver from obesity-prone (C57BL/6J) and obesity-resistant (A/J) mice
Mice were fed for 2, 10 or 30 days with a normal chow (NC) or a high fat diet (HFD). At each time point, mice were sacrificed and liver samples were collected and immediately frozen in liquid nitrogen. Total RNA from each sample was further extracted, purified, quality-controled before and after amp...
ORGANISM(S): Mus musculus 
2009-08-09 | E-GEOD-12409 | biostudies-arrayexpress
ProteomicsTargeting Fibrillarin-mediated ribosomal RNA maturation as a novel therapeutic vulnerability in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is among the most challenging breast cancer subtypes to treat due to the lack of effective therapeutic options. Ribosome biogenesis has recently emerged as a promising therapeutic target across various cancers. Current ribosome biogenesis inhibitors primarily tar...
ORGANISM(S): Homo sapiens (Human) 
2025-11-24 | PXD060027 | Pride
Label-free quantitative proteomics Targeting ribosome biogenesis Nanolc-ms/ms Triple-negative breast cancer 
TranscriptomicsEffect of rimonabant on gene expression of visceral and subcutaneous adipose tissues: high fat diet
Mice were fed for 6 months with a normal chow (NC) or a high fat diet (HFD). After 6 months of diet, high fat fed mice with Low, Medium and High body weight, but with similar glucose intolerance, were selected. These selected mice as well as NC mice were then treated with Rimonabant or Vehicle for 1...
ORGANISM(S): Mus musculus 
2008-12-14 | E-GEOD-11790 | biostudies-arrayexpress
ProteomicsVolpatti_Myopathy_P124_Lumos_VS8
This dataset consists of 9 raw MS files, acquired on Orbitrap Fusion Lumos Tribrid mass spectrometer operated in Data Dependent Acquisition mode. Cells and lysates were generated by Jonathan Volpatti. Sample processing and mass spectrometry acquisition was performed by Cassandra Wong. Data analysis...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-07-12 | MSV000089872 | MassIVE
TranscriptomicsTranscription profiling of indole-3-acetic acid at physiological concentrations (IAA) treatment of Arabidopsis seedlings
To demonstrate the analysis of differential expression using CATMA v1 arrays, Arabidopsis seedlings were treated with indole-3-acetic acid at physiological concentrations. The seedlings were germinated in liquid medium, and treated with indole-3-acetic acid for 30, 120 or 240 minutes. Changes in exp...
ORGANISM(S): Arabidopsis thaliana 
2004-05-31 | E-MEXP-65 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis mutants (elo2, elo3, drl1-2 and ang4) vs the wild type Ler strain
Microarray transcript profiling and RNA interference are two new technologies crucial for large-scale gene function studies in multicellular eukaryotes. Both rely on sequence-specific hybridization between complementary nucleic acid strands, inciting us to create a collection of gene-specific sequen...
ORGANISM(S): Arabidopsis thaliana 
2004-05-07 | E-MEXP-30 | biostudies-arrayexpress
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