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TranscriptomicsRNA-seq melanoma
Using a chromatin regulator-focused shRNA library, we found that suppression of sex determining region Y-box 10 (SOX10) in melanoma causes resistance to BRAF and MEK inhibitors. To investigate how SOX10 loss leads to drug resistance, we performed transcriptome sequencing (RNAseq) of both parental A...
ORGANISM(S): Homo sapiens 
2014-01-04 | E-GEOD-50535 | biostudies-arrayexpress
TranscriptomicsThe cancer SENESCopedia – delineation of cancer cell senescence
We analyzed a panel of 13 cancer cell lines rendered senescent by either etoposide (7 day treatment) or alisertib (7 and 14 day treatment). We aimed to find common vulnerabilities to induce cell death, and shared features that would allow unambiguous identification of the senescent state in the cont...
ORGANISM(S): Homo sapiens 
2021-07-18 | E-MTAB-9970 | biostudies-arrayexpress
UnknownThe phosphatase inhibitor LB-100 creates neoantigens in colon cancer cells through perturbation of mRNA splicing
Not available
S-SCDT-10_1038-S44319-024-00128-3 | biostudies-other
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