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ProteomicsPregnancy alters fatty acid metabolism, glucose regulation, and detoxification of the liver in synchrony with biomechanical property changes
Pregnancy places a metabolic burden on the body including the liver, which is responsible for ensuring adequate nutrition for the maternal and fetal systems. To gain a better understanding of liver adaptation, this study investigates metabolic shifts occurring in livers of pregnant rats. Metabolic c...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-10-22 | PXD050758 | Pride
Pregnancy Metabolic Structural liver changes 
ProteomicsAltered Brain Energy Metabolism in the APPPS1 Alzheimer’s Mouse Model during Anesthesia
Background: Synaptic transmission and network activity rely on high ATP turnover. Impairments in cerebral energy metabolism are increasingly recognized as central to aging and the pathogenesis of Alzheimer’s disease (AD). AD is related to elevated risk for perioperative neurological complications, i...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-08 | PXD072113 | Pride
ModelsBulik2016 - Regulation of hepatic glucose metabolism
Bulik2016 - Regulation of hepatic glucose metabolism This model is described in the article: The relative importance of kinetic mechanisms and variable enzyme abundances for the regulation of hepatic glucose metabolism--insights from mathematical modeling. Bulik S, Holzhüt...
2024-09-02 | BIOMD0000000633 | BioModels
ProteomicsComputational Modelling of Myocardial Metabolism in Patients with Advanced Heart Failure
Although perturbations of myocardial metabolism and energy depletion are fundamental characteristics of heart failure (HF) pathophysiology, interindividual variability in bioenergetic phenotypes and their clinical implications remain poorly understood. Here, we used large-scale proteomics data from ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-10 | PXD053721 | Pride
Metabolism Computational modelling Heart failure Ventricular assist device Precision medicine 
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