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Our understanding of metabolic interactions between small symbiotic animals and bacteria or parasitic eukaryotes that reside within their bodies is extremely limited. This gap in knowledge originates from a methodological challenge, namely to connect histological changes in host tissues induced by b...
2021-07-06 | MTBLS2639 | MetaboLights
Fusarium graminearum and related species commonly infest grains causing the devastating plant disease Fusarium head blight (FHB) and the formation of trichothecene mycotoxins. The most relevant toxin is deoxynivalenol (DON), which acts as a virulence factor of the pathogen. FHB is difficult to contr...
2014-10-17 | MTBLS112 | MetaboLights
Timecourse analysis of SRF dependent genes in the nascent mesoderm of mouse embryos. Srf was conditionally deleted by a T::cre driver and the three embryonic stages analyzed represent embryos before onset of the phenotype (E8.5) and progressive appearance of the phenotype (E8.75 and E9.0). Total RNA...
ORGANISM(S): Mus musculus 
Glioblastoma (GBM) is an incurable brain tumor carrying a dismal prognosis, which displays considerable heterogeneity. We have recently identified recurrent H3F3A mutations affecting two critical positions of histone H3.3 (K27, G34) in one-third of pediatric GBM. Here we show that each of these H3F3...
ORGANISM(S): Homo sapiens 
The outcome of patients with anaplastic gliomas varies considerably depending on histology and single molecular markers such as codeletion of 1p/19q and mutations of the isocitrate dehydrogenase (IDH) gene. Whether a molecularly-based classification of anaplastic gliomas based on large scale genomic...
ORGANISM(S): Homo sapiens 
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