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TranscriptomicsA high throughput in vivo protein-DNA mapping approach reveals principles of dynamic gene regulation in mammals (RNA-Seq)
Dynamic binding of transcription factors to DNA elements specifies gene expression and cell fate, in both normal physiology and disease. To date, our understanding of mammalian gene regulation has been hampered by the difficulty of directly measuring in vivo binding of large numbers of transcription...
ORGANISM(S): Mus musculus 
2012-09-11 | E-GEOD-36103 | biostudies-arrayexpress
MetabolomicsMass spectrometry imaging as an emerging tool for studying metabolism in human brain organoids

Human brain organoids are emerging models to study human brain development and pathology as they recapitulate the development and characteristics of major neural cell types, and enable manipulation through an in vitro system. Over the past decade, with the advent of spatial technologies,...

2023-05-23 | MTBLS7565 | MetaboLights
UnknownVoxel-wise insights into early Alzheimer's disease pathology progression: the association with APOE and memory decline.
Not available
S-EPMC12397024 | biostudies-literature
UnknownCharacterizing Heterogeneity in Neuroimaging, Cognition, Clinical Symptoms, and Genetics Among Patients With Late-Life Depression.
Not available
S-EPMC8908227 | biostudies-literature
UnknownFeasibility of Prospectively Comparing Opioid Analgesia With Opioid-Free Analgesia After Outpatient General Surgery: A Pilot Randomized Clinical Trial.
Not available
S-EPMC9294998 | biostudies-literature
UnknownMost common 'sporadic' cancers have a significant germline genetic component.
Not available
S-EPMC4271103 | biostudies-literature
UnknownSPTSSA variants alter sphingolipid synthesis and cause a complex hereditary spastic paraplegia.
Not available
S-EPMC10319774 | biostudies-literature
UnknownAltered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy.
Not available
S-EPMC8608736 | biostudies-literature
UnknownDe Novo Mutations in CHD4, an ATP-Dependent Chromatin Remodeler Gene, Cause an Intellectual Disability Syndrome with Distinctive Dysmorphisms.
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S-EPMC5065651 | biostudies-literature
UnknownGermline De Novo Mutations in GNB1 Cause Severe Neurodevelopmental Disability, Hypotonia, and Seizures.
Not available
S-EPMC4863562 | biostudies-literature
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