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TranscriptomicsYeast spores genotyping to analyze the fate of meiotic DNA double strand breaks
Yeast spores genotyping to analyze the fate of meiotic DNA double strand breaks. For control crossovers are recirpocal events based on the information from two independent spore hybridizations from a unique tetrad were used. Genotyping procedure followed as described in Bourgon et al 2009
ORGANISM(S): Saccharomyces cerevisiae 
2012-01-01 | E-MTAB-508 | biostudies-arrayexpress
Transcriptomicssingle cell RNAseq of memory B cells in the context of rituximab-treated ITP patients
Rituximab (RTX) is widely used as a first-line therapeutic strategy in B cell-mediated autoimmune diseases. However, a large proportion of patients either do not respond to the treatment or relapse during B cell reconstitution. Primary immune thrombocytopenia (ITP) is a prototypic B cell mediated au...
ORGANISM(S): Homo sapiens 
2021-01-31 | E-MTAB-9955 | biostudies-arrayexpress
TranscriptomicsAMPK epidermal inhibition promotes HuR cytoplasmic localization eliciting post-transcriptional inflammatory response in psoriasis
IL-20 cytokines are involved in the establishment of psoriasis, a common chronic skin inflammation epidemiologically associated with metabolic syndrome, but molecular mechanisms underlying their over-expression remain to be elucidated. We find that keratinocytes (KCs) expressed IL-20 and lymphocytes...
ORGANISM(S): Homo sapiens 
2015-09-08 | E-GEOD-50598 | biostudies-arrayexpress
ProteomicsProteomic analysis of urinary exosomes in cystinuria patients
Cystinuria is a rare renal genetic disease caused by mutations in cystine transporter genes and characterized by defective cystine reabsorption leading to kidney stones. In 14% of cases patients undergo nephrectomy, but given the difficulty to predict the evolution of the disease, the identification...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-01 | MSV000079546 | MassIVE
TranscriptomicsAntibody mRNA-seq repertoire sequencing to study relapses after B-cell depletion therapy
Rituximab (RTX) is widely used as a first-line therapeutic strategy for patients affected by immune thrombocytopenia (ITP). However, a large proportion of patients relapse after successful treatment. The present NGS assay was done to help find the cause for this relapse on the immune repertoire leve...
ORGANISM(S): Homo sapiens 
2021-01-18 | E-MTAB-9953 | biostudies-arrayexpress
UnknownEfficacy and Safety of Obinutuzumab in Immune-Mediated Thrombotic Thrombocytopenic Purpura.
Not available
S-EPMC11705199 | biostudies-literature
UnknownAnti-ADAMTS13 Antibodies Trajectory is Associated With ADAMTS13 Recovery in Immune-Mediated TTP.
Not available
S-EPMC12417756 | biostudies-literature
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