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TranscriptomicsGene expression profiling of human tissue samples using SAGE-Seq
We present a powerful application of ultra high-throughput sequencing, SAGE-Seq, for the accurate quantification of normal and neoplastic mammary epithelial cell transcriptomes. We develop data analysis pipelines that allow the mapping of sense and antisense strands of mitochondrial and RefSeq genes...
ORGANISM(S): Homo sapiens 
2010-10-05 | E-GEOD-24491 | biostudies-arrayexpress
TranscriptomicsAltered antisense-to-sense transcript ratios in breast cancer: Sage-Seq
Transcriptome profiling studies suggest that a large fraction of the genome is transcribed and many transcripts function independent of their protein coding potential. The relevance of noncoding RNAs (ncRNAs) in normal physiological processes and in tumorigenesis is increasingly recognized. Here, we...
ORGANISM(S): Homo sapiens 
2010-12-10 | E-GEOD-25291 | biostudies-arrayexpress
TranscriptomicsSystem-based analyses of brain regions functionally impacted in Parkinson's disease reveals underlying causal mechanisms
Detailed analysis of disease-affected tissue provides insight into molecular mechanisms contributing to pathogenesis. Substantia nigra, striatum and cortex are functionally connected with increasing degrees of alpha-synuclein pathology in Parkinson's disease. Functional and causal pathway analysis o...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-54282 | biostudies-arrayexpress
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